如何通过“点击”化学非常高效地对金纳米颗粒进行功能化修饰。
How to very efficiently functionalize gold nanoparticles by "click" chemistry.
作者信息
Boisselier Elodie, Salmon Lionel, Ruiz Jaime, Astruc Didier
机构信息
Institut des Sciences Moléculaires, UMR CNRS No. 5255, Université Bordeaux 1, 33405, Talence Cedex, France.
出版信息
Chem Commun (Camb). 2008 Nov 30(44):5788-90. doi: 10.1039/b812249k. Epub 2008 Oct 1.
Difficulties previously encountered in the very useful "click" functionalization of gold nanoparticles (AuNPs) resulting in low yields are now overcome by using specific conditions: 1:1 water-THF medium, stoichiometric CuSO(4) and sodium ascorbate, inert atmosphere at 20 degrees C that provide quantitative "click" reactions between azidoalkylthiolate-AuNPs with various hydrophilic (PEG-containing) and hydrophobic (organic and organometallic) alkynes.
以前在金纳米颗粒（AuNPs）非常有用的“点击”功能化过程中遇到的导致产率低的困难，现在通过使用特定条件得以克服：1:1的水 - 四氢呋喃介质、化学计量的硫酸铜和抗坏血酸钠、20摄氏度的惰性气氛，这些条件能使叠氮烷基硫醇盐 - AuNPs与各种亲水性（含聚乙二醇）和疏水性（有机和有机金属）炔烃之间发生定量的“点击”反应。
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