细胞受体与丙型肝炎病毒进入

Cellular receptors and HCV entry.

作者信息

Flint Mike, Tscherne Donna M

机构信息

Wyeth Antiviral Research, Pearl River, NY, USA.

出版信息

Methods Mol Biol. 2009;510:265-77. doi: 10.1007/978-1-59745-394-3_20.

DOI:10.1007/978-1-59745-394-3_20

PMID:19009268

Abstract

After attachment to specific receptors on the surfaces of target cells, hepatitis C virus (HCV) particles are thought to be internalized to endosomes, where low pH induces fusion between the viral and cellular membranes, delivering the HCV genome into the cytoplasm. Here, we describe methods to study the early events in HCV infection; the interactions with cellular receptors and the mechanism of entry.

摘要

在附着于靶细胞表面的特定受体后，丙型肝炎病毒（HCV）颗粒被认为会内化至内体，在那里低pH值诱导病毒膜与细胞膜融合，将HCV基因组递送至细胞质中。在此，我们描述了研究HCV感染早期事件的方法；与细胞受体的相互作用以及进入机制。