Stranjalis George, Tsamandouraki Kyriaki, Gazonis Stergios, Martzoukos Alexandros, Mavroforou Evagelia, Metallinos Alexandros, Ovales Constantinos, Papoulias Emmanuel, Spigos Constantinos, Voulgaris Alexandros, Sakas Damianos, Alamanos Yannis
Department of Neurosurgery, University of Athens, Evagelismos Hospital, Athens, Greece.
Seizure. 2009 Apr;18(3):206-10. doi: 10.1016/j.seizure.2008.09.007. Epub 2008 Nov 14.
The aim of the present study was to investigate the epidemiologic profile of epileptic seizures in the general population of a defined area of Northwest Greece. We also investigated the frequency of epilepsy in the same population.
The study area was the District of Corfu representing a population of about 11,3000 inhabitants. Cases have been recorded prospectively in the frame of a systematic recording system, using multiple sources of retrieval, developed in the study area. All patients referred between 1 July 2004 and 30 June 2005, representing a case of diagnosed epilepsy or a new case of epileptic seizure, resident in the study area, were included in the study. Cases were confirmed and classified according to ILAE guidelines for epidemiologic studies on epilepsy.
A total of 68 new cases of epileptic seizures were recorded. The age adjusted mean annual incidence rate was 58.4 (95% CI, 43.9-72.9) cases per 10(5) inhabitants (55.6 for men, and 62.3 for women). Thirty-seven cases were classified as unprovoked seizures (32.6 cases per 10(5)), and 13 of them were related to stable conditions. The age adjusted prevalence estimate of diagnosed epilepsy was 226.1 (95% CI, 199.4-252.7) cases per 10(5) inhabitants (223.3 for men, and 228.6 for women).
The study population presents a relatively low incidence of unprovoked seizures and a low frequency of epilepsy, in comparison to other populations studied. The low incidence of unprovoked seizures seems to be related to a low occurrence of cases associated with conditions resulting to a static encephalopathy.
本研究旨在调查希腊西北部特定区域普通人群中癫痫发作的流行病学特征。我们还调查了同一人群中癫痫的发病率。
研究区域为科孚岛地区，约有113000名居民。病例通过在研究区域建立的系统记录系统进行前瞻性记录，该系统使用多种检索来源。纳入研究的患者为2004年7月1日至2005年6月30日期间转诊的、居住在研究区域且被诊断为癫痫或新发癫痫发作的病例。病例根据国际抗癫痫联盟（ILAE）癫痫流行病学研究指南进行确诊和分类。
共记录了68例新发癫痫发作病例。年龄调整后的年平均发病率为每10（5）名居民58.4例（95%可信区间，43.9 - 72.9）（男性为55.6例，女性为62.3例）。37例被分类为特发性发作（每10（5）例中有32.6例），其中13例与稳定病情相关。年龄调整后的确诊癫痫患病率估计为每10（5）名居民226.1例（95%可信区间，199.4 - 252.7）（男性为223.3例，女性为228.6例）。
与其他研究人群相比，本研究人群的特发性发作发病率相对较低，癫痫发病率也较低。特发性发作的低发病率似乎与导致静态脑病的疾病相关病例发生率较低有关。
