Hotte Sebastien J, Wright James R
Department of Oncology, McMaster University, 699 Concession Street, Hamilton, Ontario L8V 5C2, Canada.
Hematol Oncol Clin North Am. 2008 Dec;22(6):1257-66, x. doi: 10.1016/j.hoc.2008.09.001.
Clinical trials evaluating therapies in patients who have head and neck cancer are often challenged by low power and competing clinical outcomes, which makes interpretation difficult. Meta-analyses that combine the results of independent trials have the potential to provide high-quality, evidence-based information on what should be considered best practice beyond that of any one trial. In this summary of published meta-analyses, the authors review the evidence supporting the use of concurrent chemotherapy and fractionated radiotherapy for patients who have locally advanced squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx.
评估头颈部癌患者治疗方法的临床试验常常受到低效能和相互竞争的临床结果的挑战，这使得结果解读变得困难。综合独立试验结果的荟萃分析有潜力提供高质量的、基于证据的信息，以明确超越任何单个试验的最佳实践。在这份已发表的荟萃分析总结中，作者回顾了支持对局部晚期口腔、口咽、下咽和喉鳞状细胞癌患者使用同步化疗和分次放疗的证据。
