用油酸乙醇胺治疗静脉畸形。
Treatment of venous malformations with ethanolamine oleate.
作者信息
Das Bijoy Krishna, Hoque Shafiqul
机构信息
Department of Paediatric Surgery, Gono-Shasthaya Samaj Vittik Medical College, Dhaka, Bangladesh.
出版信息
Asian J Surg. 2008 Oct;31(4):220-4. doi: 10.1016/S1015-9584(08)60091-3.
OBJECTIVE
To describe the outcome and complications following ethanolamine oleate treatment of venous malformations.
METHODS
Seventy-two patients (27 male, 45 female; age range, 3 months to 16 years) with 76 lesions were treated with ethanolamine oleate at 0.50-16 mL per session, with a maximum dose of 0.40 mL/kg. All patients were evaluated 8 weeks after the final injection and were followed-up for about 1 year. All the patients were treated on a day-case basis except for one who required general anaesthesia.
RESULTS
Seventy-six lesions underwent 149 sclerotherapy sessions, with 41 requiring one session, 21 requiring two and 14 requiring more than two. Ethanolamine oleate significantly improved five lesions and completely resolved symptoms in 71. All patients experienced pain and swelling to a variable degree for a short time. Skin sloughing took place in three patients. No other complications were observed.
CONCLUSION
Treatment of venous malformations with ethanolamine oleate is safe and effective.
目的
描述油酸乙醇胺治疗静脉畸形后的疗效及并发症。
方法
72例患者（男27例，女45例；年龄范围3个月至16岁）共76处病灶接受油酸乙醇胺治疗，每次剂量为0.50 - 16 mL，最大剂量为0.40 mL/kg。所有患者在最后一次注射后8周进行评估，并随访约1年。除1例需要全身麻醉外，所有患者均在日间病房接受治疗。
结果
76处病灶接受了149次硬化治疗，其中41处只需1次治疗，21处需2次，14处需2次以上。油酸乙醇胺使5处病灶明显改善，71处病灶症状完全缓解。所有患者均在短时间内出现不同程度的疼痛和肿胀。3例患者出现皮肤脱落。未观察到其他并发症。
结论
油酸乙醇胺治疗静脉畸形安全有效。
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