Singer P, Rothkopf M M, Kvetan V, Kirvelä O, Gaare J, Askanazi J
Department of Anesthesiology, Montefiore Medical Center, Bronx, New York 10467.
JPEN J Parenter Enteral Nutr. 1991 Jan-Feb;15(1):75-9. doi: 10.1177/014860719101500175.
The gastrointestinal tract is a major target of the human immunodeficiency virus. Many AIDS patients have weight loss and/or diarrhea. Parenteral nutrition can be used to treat malnutrition associated with malabsorption. We reviewed retrospectively the clinical course of 22 patients with AIDS and weight loss greater than 10% who received home parenteral nutrition (HPN) for 56.2 patient-months. Mean weight loss was 21.4%, mean duration of HPN 2.55 months, mean age 37.4 years. Fifteen patients gained weight, six stabilized and two continued to lose weight. Nine patients returned to previous activity. Five died. The rates of catheter-related sepsis, complications, and metabolic disturbances were 0.12, 0.25, and 0.12/100 catheter days, respectively, results identical to those reported in other patient populations where HPN is commonly applied. We found that HPN induced weight gain and clinical improvement in most patients without higher risks of sepsis than in patients with malignancies.
胃肠道是人类免疫缺陷病毒的主要靶器官。许多艾滋病患者会出现体重减轻和/或腹泻。肠外营养可用于治疗与吸收不良相关的营养不良。我们回顾性分析了22例体重减轻超过10%的艾滋病患者接受家庭肠外营养（HPN）共56.2患者月的临床过程。平均体重减轻21.4%，HPN平均持续时间2.55个月，平均年龄37.4岁。15例患者体重增加，6例体重稳定，2例继续体重减轻。9例患者恢复到之前的活动水平。5例死亡。导管相关败血症、并发症和代谢紊乱的发生率分别为0.12、0.25和0.12/100导管日，结果与其他普遍应用HPN的患者群体报告的结果相同。我们发现，HPN使大多数患者体重增加并临床改善，且败血症风险并不高于恶性肿瘤患者。
