Unit of Ophthalmology, School of Clinical Sciences, University of Liverpool, Liverpool, UK.
Eye (Lond). 2009 Sep;23(9):1851-8. doi: 10.1038/eye.2008.351. Epub 2008 Nov 14.
To investigate the involvement of retinal pigment epithelial (RPE) cells in reactive retinal glioangiosis (RRG; known also as retinal vasoproliferative tumour or massive retinal gliosis).
Nine RRG lesions (six in enucleated eyes and three endoresection specimens) were studied employing histological methods. Eight of the nine lesions were also subjected to immunohistochemical evaluation of glial and RPE cell content.
All lesions consisted of masses within the sensory retina that contained glial cells, abnormal blood vessels, and scattered melanin pigment. Epi- and subretinal membranes were also observed in association with the RRG lesions in all six enucleated eyes (retinal surfaces could not be examined in endoresection specimens). Immunohistochemistry revealed RPE cells in seven of eight RRG lesions and in the associated periretinal membranes. These RPE cells were typically fibroblastic or macrophage-like in phenotype and, within RRG lesions, often perivascular in location. Glia represented the majority of cells in the retinal masses.
The findings indicate that RPE cells may be involved in RRG. The observations engender speculation that RRG represents a part of the spectrum of proliferative vitreoretinopathy, in which case therapies designed to counter proliferative vitreoretinopathy might also have a role in the management of RRG.
研究视网膜色素上皮 (RPE) 细胞在反应性视网膜胶质增生症 (RRG；也称为视网膜血管性增殖瘤或弥漫性视网膜胶质增生) 中的作用。
研究了 9 个 RRG 病变（6 个在眼内容剜除眼中，3 个在内眼切除标本中），采用组织学方法。在 9 个病变中，有 8 个还进行了 RPE 细胞和神经胶质细胞含量的免疫组织化学评估。
所有病变均为位于感觉视网膜内的肿块，包含神经胶质细胞、异常血管和散在的黑色素。在 6 个眼内容剜除眼中，还观察到与 RRG 病变相关的视网膜下和视网膜内膜（在眼内切除标本中无法检查视网膜表面）。免疫组织化学显示，在 8 个 RRG 病变中的 7 个和相关的视网膜周围膜中有 RPE 细胞。这些 RPE 细胞在表型上通常呈成纤维细胞或巨噬细胞样，在 RRG 病变中，通常位于血管周围。神经胶质细胞是视网膜肿块中大多数细胞。
这些发现表明 RPE 细胞可能参与 RRG。这些观察结果表明，RRG 可能是增生性玻璃体视网膜病变谱的一部分，在这种情况下，旨在对抗增生性玻璃体视网膜病变的治疗方法也可能在 RRG 的治疗中发挥作用。
