Erikssen J, Eidsaunet W, Thaulow E, Røde R, Myhre E
Medisinsk avdeling, Sentralsykehuset i Akershus, Nordbyhagen.
Tidsskr Nor Laegeforen. 1991 Feb 20;111(5):577-82.
A randomized double blind comparison of transdermal nitroglycerin and isosorbide dinitrate tablets was conducted in 100 men with stable angina pectoris. Subjective and objective effects were virtually identical for both regimens (number of angina attacks/nitroglycerin consumption and exercise ECG test variables). The pattern of side effects was also similar for both drugs. A considerable dissociation was observed between subjective effects and effects measured by ergometer test in the individual patient. Lack of both subjective and objective effects--i.e. nitrate tolerance--was observed in approximately one fourth of the patients, and was not prevented by a twelve-hour dosing interval on isosorbide dinitrate nor a six hour transdermal nitroglycerin-free interval. Our data lends credence to the notion that the effects of long-acting nitrates in daily life and the effects measured during stress testing may involve different mechanisms.
对100例稳定型心绞痛男性患者进行了一项随机双盲比较，比较经皮硝酸甘油和硝酸异山梨酯片。两种治疗方案的主观和客观效果几乎相同（心绞痛发作次数/硝酸甘油消耗量以及运动心电图测试变量）。两种药物的副作用模式也相似。在个体患者中，主观效果与测力计测试所测效果之间存在相当大的分离。在大约四分之一的患者中观察到主观和客观效果均缺乏，即硝酸盐耐受性，并且硝酸异山梨酯12小时给药间隔或经皮硝酸甘油6小时无药间隔均不能预防这种情况。我们的数据支持这样一种观点，即长效硝酸盐在日常生活中的效果与应激测试期间所测效果可能涉及不同机制。
