Hofmann W P, Rädle J, Moench C, Bechstein W, Zeuzem S
Medizinische Klinik 1, Klinikum der Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Z Gastroenterol. 2008 Nov;46(11):1283-9. doi: 10.1055/s-2008-1027624. Epub 2008 Nov 14.
Patients with advanced liver disease show increased morbidity and mortality after hepatic resection and non-hepatic digestive surgery. Furthermore, postoperative liver failure is associated with a poor outcome, representing an important clinical problem. For evaluation of the perioperative mortality and the hepatic function, several scoring systems, clinical parameters, and static and dynamic tests are available. Recently, the Model for End-Stage Liver Disease (MELD) has been shown to provide a complementary predictive value to the widely used Child Turcotte Pugh score. Patients with Child Turcotte Pugh class C cirrhosis and MELD scores >14 are generally not considered for surgical intervention. Patients with Child Turcotte Pugh class B cirrhosis and MELD scores >8-14 have an increased perioperative risk and the indication for surgery should be assessed carefully. In patients with Child Turcotte Pugh class A cirrhosis and MELD scores of <or= 8, perioperative mortality is low. Although not routinely used, dynamic tests can provide additional information on the expected residual hepatic function in patients with Child Turcotte Pugh class A cirrhosis and MELD scores of <or= 8 in whom hepatic resection is needed. Besides other dynamic tests, the indocyanine green (ICG) clearance and the monoethylglycinxylid (MEGX) clearance tests have been satisfactorily evaluated.
晚期肝病患者在肝切除和非肝脏消化系统手术后发病率和死亡率增加。此外,术后肝衰竭与不良预后相关,是一个重要的临床问题。为评估围手术期死亡率和肝功能,有多种评分系统、临床参数以及静态和动态检查方法可供使用。最近,终末期肝病模型(MELD)已被证明可为广泛使用的Child Turcotte Pugh评分提供补充预测价值。Child Turcotte Pugh C级肝硬化且MELD评分>14的患者通常不考虑手术干预。Child Turcotte Pugh B级肝硬化且MELD评分>8 - 14的患者围手术期风险增加,应仔细评估手术指征。Child Turcotte Pugh A级肝硬化且MELD评分≤8的患者围手术期死亡率较低。尽管动态检查并非常规使用,但对于需要进行肝切除的Child Turcotte Pugh A级肝硬化且MELD评分≤8的患者,动态检查可提供有关预期残余肝功能的额外信息。除其他动态检查外,吲哚菁绿(ICG)清除率和单乙基甘氨酰二甲苯胺(MEGX)清除率检查已得到满意评估。