Truini A, Galeotti F, Biasiotta A, Gabriele M, Inghilleri M, Petrucci M T, Cruccu G
Department of Neurological Sciences, La Sapienza University, Viale Università 30, Rome, Italy.
Muscle Nerve. 2009 Mar;39(3):369-73. doi: 10.1002/mus.21162.
In this study we investigate whether the cutaneous silent period (CSP)-an inhibitory response evoked in hand muscles by painful digital nerve stimulation-is useful for assessing nociceptive pathway function in patients with neuropathic pain. In 40 patients with peripheral neuropathy (21 without and 19 with neuropathic pain) we recorded the CSP in the abductor digiti minimi after fifth digit stimulation and also recorded laser evoked potentials (LEPs) after stimulation applied to the ulnar territory of the hand. Although the LEP amplitude was significantly lower in patients with pain than in those without (P < 0.005), the CSP duration did not differ between groups (P > 0.50). Pain intensity correlated significantly with LEP amplitudes (P < 0.005) but not with CSP duration (P > 0.5). Our findings indicate that the CSP is not useful for assessing nociceptive pathway function in patients with neuropathic pain.
在本研究中，我们调查了皮肤静息期（CSP）——一种由手指神经疼痛刺激引起的手部肌肉抑制性反应——是否有助于评估神经性疼痛患者的伤害性感受通路功能。在40例周围神经病变患者（21例无神经性疼痛，19例有神经性疼痛）中，我们记录了刺激小指后在小指展肌中的CSP，并且在刺激手部尺侧区域后记录了激光诱发电位（LEP）。虽然疼痛患者的LEP波幅显著低于无疼痛患者（P < 0.005），但两组之间的CSP持续时间并无差异（P > 0.50）。疼痛强度与LEP波幅显著相关（P < 0.005），但与CSP持续时间无关（P > 0.5）。我们的研究结果表明，CSP无助于评估神经性疼痛患者的伤害性感受通路功能。
