停止促性腺激素治疗无排卵性不孕症后自然妊娠率的提高。

Improvement of spontaneous pregnancy rate after stopping gonadotropin therapy for anovulatory infertility.

作者信息

Aboulghar M A, Mansour R T, Serour G I, Rizk P, Riad R

机构信息

Egyptian IVF-ET Center, Cairo University.

出版信息

Fertil Steril. 1991 Apr;55(4):722-5. doi: 10.1016/s0015-0282(16)54237-x.

DOI:10.1016/s0015-0282(16)54237-x

PMID:1901280

Abstract

In a prospective study, 140 patients with infertility because of ovulatory factors (group A) were followed up for 6 months after failure to achieve pregnancy using human menopausal gonadotropin (hMG) therapy. They included cases of oligomenorrhea, polycystic ovarian disease (PCOD), and hypogonadotropic amenorrhea. They were treated with hMG alone or in combination with clomiphene citrate or gonadotropin-releasing hormone agonist analog. The control group (B) included 83 infertile patients because of similar ovulatory factors. They were followed up for 6 months not preceded by ovulation induction. The overall pregnancy rate (PR) in group A (20.7%) was significantly higher than group B (7.2%). The PR was significantly higher in oligomenorrhea and PCOD patients when compared with the control group. There was no significant difference in the hypogonadotropic group.

摘要

在一项前瞻性研究中，140例因排卵因素导致不孕的患者（A组）在使用人绝经期促性腺激素（hMG）治疗未能受孕后，接受了6个月的随访。这些患者包括月经过少、多囊卵巢疾病（PCOD）和低促性腺激素性闭经的病例。他们单独使用hMG治疗，或与枸橼酸氯米芬或促性腺激素释放激素激动剂类似物联合使用。对照组（B组）包括83例因类似排卵因素导致不孕的患者。他们在未进行促排卵的情况下接受了6个月的随访。A组的总体妊娠率（PR）（20.7%）显著高于B组（7.2%）。与对照组相比，月经过少和PCOD患者的妊娠率显著更高。低促性腺激素组之间没有显著差异。