寻找合适的伴侣：科学还是艺术？
Finding the right partner: science or ART?
作者信息
Polo Simona, Di Fiore Pier Paolo
机构信息
IFOM, Istituto FIRC di Oncologia Molecolare, Milano, Italy.
出版信息
Cell. 2008 Nov 14;135(4):590-2. doi: 10.1016/j.cell.2008.10.032.
PMID:19013267
Abstract
In response to environmental cues, certain plasma membrane proteins are ubiquitinated, signaling their endocytosis and degradation. In the budding yeast, a single enzyme, Rsp5, is charged with this task. Lin et al. (2008) now identify an arrestin-related family of Rsp5 adaptor proteins called ARTs that confer specificity on the ubiquitination of plasma membrane proteins and contribute to the maintenance of the correct cell surface protein repertoire.
摘要
作为对环境信号的响应，某些质膜蛋白会被泛素化，从而发出内吞和降解的信号。在出芽酵母中，一种名为Rsp5的单一酶负责这项任务。林等人（2008年）现在鉴定出了一个与Rsp5衔接蛋白相关的抑制蛋白家族，称为ARTs，它们赋予质膜蛋白泛素化特异性，并有助于维持正确的细胞表面蛋白库。
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