病毒与肾脏疾病：超越艾滋病毒
Viruses and kidney disease: beyond HIV.
作者信息
Waldman Meryl, Marshall Vickie, Whitby Denise, Kopp Jeffrey B
机构信息
Kidney Disease Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1268, USA.
出版信息
Semin Nephrol. 2008 Nov;28(6):595-607. doi: 10.1016/j.semnephrol.2008.08.010.
Human immunodeficiency virus (HIV)-infected patients may acquire new viral co-infections; they also may experience the reactivation or worsening of existing viral infections, including active, smoldering, or latent infections. HIV-infected patients may be predisposed to these viral infections owing to immunodeficiency or risk factors common to HIV and other viruses. A number of these affect the kidney, either by direct infection or by deposition of immune complexes. In this review we discuss the renal manifestations and treatment of hepatitis C virus, BK virus, adenovirus, cytomegalovirus, and parvovirus B19 in patients with HIV disease. We also discuss an approach to the identification of new viral renal pathogens, using a viral gene chip to identify viral DNA or RNA.
感染人类免疫缺陷病毒（HIV）的患者可能会发生新的病毒合并感染；他们也可能经历现有病毒感染的重新激活或恶化，包括活动性、隐匿性或潜伏性感染。由于免疫缺陷或HIV与其他病毒共有的危险因素，HIV感染患者可能易患这些病毒感染。其中一些病毒感染通过直接感染或免疫复合物沉积影响肾脏。在本综述中，我们讨论了HIV感染患者中丙型肝炎病毒、BK病毒、腺病毒、巨细胞病毒和细小病毒B19的肾脏表现及治疗。我们还讨论了一种使用病毒基因芯片鉴定病毒DNA或RNA来识别新的病毒性肾脏病原体的方法。
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