Sun Hsin-Yun, Singh Nina
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Int J Antimicrob Agents. 2008 Nov;32 Suppl 2:S115-8. doi: 10.1016/S0924-8579(08)70011-6.
Zygomycetes are being increasingly recognised as important opportunistic pathogens in immunocompromised hosts, including transplant recipients. Conflicting data exist with regard to the contribution of newer antifungal agents such as voriconazole as risk factors for zygomycosis. Although survival rates have improved, outcomes in patients with zygomycosis remain suboptimal. Combination antifungal therapies as well as unique interactions of calcineurin inhibitor immunosuppressive agents with antifungals have potentially relevant implications for optimising outcomes in zygomycosis.
接合菌越来越被认为是免疫功能低下宿主（包括移植受者）中的重要机会性病原体。关于新型抗真菌药物（如伏立康唑）作为接合菌病危险因素的作用，存在相互矛盾的数据。尽管生存率有所提高，但接合菌病患者的治疗结果仍不尽人意。联合抗真菌治疗以及钙调神经磷酸酶抑制剂免疫抑制剂与抗真菌药物的独特相互作用，对优化接合菌病的治疗结果可能具有潜在的相关意义。
