Mensa José, Pitart Cristina, Marco Francesc
Infectious Diseases Department, Hospital Clínico, Barcelona, Spain.
Int J Antimicrob Agents. 2008 Nov;32 Suppl 2:S93-7. doi: 10.1016/S0924-8579(08)70007-4.
Early initiation of effective antimicrobial therapy is crucial for the prognosis of any infection, especially in the critically ill patient. This is particularly true in the case of candidemia. However, the earlier an empirical antimicrobial regimen is started, the greater the probability of diagnostic error and the possibility of side-effects. Recent experience of the clinical efficacy and good tolerance of echinocandins in the treatment of candidemia obliges us to review the indications for empirical antifungal treatment and the choice of antifungal agent in the critically ill patient.
尽早开始有效的抗菌治疗对于任何感染的预后都至关重要，尤其是在危重症患者中。对于念珠菌血症而言尤其如此。然而，经验性抗菌治疗开始得越早，诊断错误的可能性和出现副作用的可能性就越大。棘白菌素类药物在治疗念珠菌血症方面的临床疗效和良好耐受性的最新经验促使我们重新审视危重症患者经验性抗真菌治疗的指征以及抗真菌药物的选择。
