癌症患者的生育力保存中的卵巢刺激。
Ovarian stimulation for fertility preservation in patients with cancer.
机构信息
Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology & Infertility, Stanford University, Stanford, California 94304, USA.
出版信息
Fertil Steril. 2010 Feb;93(3):865-8. doi: 10.1016/j.fertnstert.2008.10.007. Epub 2008 Nov 14.
OBJECTIVE
To evaluate controlled ovarian hyperstimulation (COH) in women with cancer compared with healthy women.
DESIGN
A retrospective cohort study.
SETTING
Academic assisted reproductive technology (ART) program.
PATIENT(S): Fifty women undergoing oocyte retrieval before cancer treatment and 50 age-matched controls.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Number of oocytes and matured oocytes retrieved, number of fertilized oocytes, days of stimulation, dose of gonadotropins.
RESULT(S): There were no significant differences in the number of oocytes retrieved (13 vs. 11.5), the number of matured oocytes retrieved (9.7 vs. 9.6), and the number of oocytes fertilized (7.4 vs. 6.8). However, the patients with cancer had a longer duration of stimulation (10.5 vs. 9.0 days) and higher total dose of gonadotropins (4,174 IU vs. 3,416 IU).
CONCLUSION(S): In our study, reasonable ovarian response was achieved by women with cancer with increased doses of gonadotropins and a longer duration of stimulation.
目的
比较癌症女性与健康女性的控制性卵巢刺激（COH）。
设计
回顾性队列研究。
地点
学术辅助生殖技术（ART）计划。
患者
50 名在癌症治疗前进行卵母细胞采集的女性和 50 名年龄匹配的对照者。
干预
无。
主要观察指标
获卵数和成熟卵数、受精卵数、刺激天数、促性腺激素剂量。
结果
获卵数（13 对 11.5）、成熟卵数（9.7 对 9.6）和受精卵数（7.4 对 6.8）无显著差异。然而，癌症患者的刺激时间更长（10.5 对 9.0 天），促性腺激素总剂量更高（4174IU 对 3416IU）。
结论
在我们的研究中，癌症女性通过增加促性腺激素剂量和延长刺激时间实现了合理的卵巢反应。
Zotero 插件