散发性肌萎缩侧索硬化症（sALS）中的循环内毒素与全身免疫激活
Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS).
作者信息
Zhang Rongzhen, Miller Robert G, Gascon Ron, Champion Stacey, Katz Jonathan, Lancero Mariselle, Narvaez Amy, Honrada Ronald, Ruvalcaba David, McGrath Michael S
机构信息
University of California, San Francisco, San Francisco, CA 94110, USA.
出版信息
J Neuroimmunol. 2009 Jan 3;206(1-2):121-4. doi: 10.1016/j.jneuroim.2008.09.017. Epub 2008 Nov 14.
Abstract
The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.
摘要
本研究报告称，与健康对照组相比，散发性肌萎缩侧索硬化症（sALS）和阿尔茨海默病（AD）患者血浆中的内毒素/脂多糖（LPS）浓度升高。疾病组血浆LPS水平与血液单核细胞/巨噬细胞活化程度呈显著正相关，在晚期sALS疾病患者中升高最为明显。sALS患者血液中血浆LPS与单核细胞/巨噬细胞IL-10表达水平之间存在显著负相关。这些数据表明，全身LPS水平和活化的单核细胞/巨噬细胞可能在sALS的发病机制中起重要作用。
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本文引用的文献
1
Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India.
Neurochem Res. 2008 Jun;33(6):1145-9. doi: 10.1007/s11064-007-9564-x. Epub 2008 Feb 2.
2
TNF and sTNFR1/2 plasma levels in ALS patients.
J Neuroimmunol. 2008 Feb;194(1-2):123-31. doi: 10.1016/j.jneuroim.2007.10.028. Epub 2008 Feb 20.
3
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.
Glia. 2007 Apr 1;55(5):453-62. doi: 10.1002/glia.20467.
4
Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Nat Med. 2006 Dec;12(12):1365-71. doi: 10.1038/nm1511. Epub 2006 Nov 19.
5
MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS).
J Neuroimmunol. 2006 Oct;179(1-2):87-93. doi: 10.1016/j.jneuroim.2006.06.008. Epub 2006 Jul 20.
6
Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.
J Neurosci. 2005 Oct 5;25(40):9275-84. doi: 10.1523/JNEUROSCI.2614-05.2005.
7
Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis.
Muscle Nerve. 2005 Oct;32(4):541-4. doi: 10.1002/mus.20376.
8
Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells.
Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Dec;5(4):213-9. doi: 10.1080/14660820410020286.
9
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