da Silva Andreza Veruska, Valones Marcela Agne, Guimaraes Renata Pedrosa, de Castro Jurema Freire Lisboa, Carvalho Alessandra de A T
Universidade Federal de Pernambuco, Recife, Brazil.
Gen Dent. 2008 Nov-Dec;56(7):700-3.
Pemphigus vulgaris (PV) is an autoimmune intra-epithelial dermatologic disease that is characterized by epithelial blistering and affected cutaneous and/or mucosal surfaces. The disease is caused by circulating immunoglobulin G (IgG) antibodies directed against desmosomes. These antibodies interfere with keratinocyte adhesion, causing acantholysis, which results in blister formation. At present, death from pemphigus infection is unusual; however, morbidity and mortality from chronic corticosteroid use remain considerable, indicating a need for additional therapies. This article presents a case of PV in a female patient that was treated with conventional corticosteroid therapy and discusses recent adjuvant therapy.
寻常型天疱疮（PV）是一种自身免疫性上皮内皮肤病，其特征为上皮水疱形成，累及皮肤和/或黏膜表面。该疾病由针对桥粒的循环免疫球蛋白G（IgG）抗体引起。这些抗体干扰角质形成细胞黏附，导致棘层松解，进而形成水疱。目前，因天疱疮感染导致死亡的情况并不常见；然而，长期使用皮质类固醇激素引起的发病率和死亡率仍然相当高，这表明需要其他治疗方法。本文介绍了一例接受传统皮质类固醇激素治疗的女性PV患者病例，并讨论了近期的辅助治疗方法。
