Cizmecioğlu Filiz M, Hatun Sükrü, Kalaça Sibel
Division of Endocrinology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Turk J Pediatr. 2008 Jul-Aug;50(4):359-65.
There is no consensus on whether or not the diagnostic criteria of metabolic syndrome (MS) defined for adults [National Cholesterol Education Panel (NCEP) and World Health Organization (WHO)] can be used in childhood as well. We aimed to compare prevalence of metabolic syndrome among obese children and adolescents using WHO and NCEP guidelines. A total of 112 obese children and adolescents were assessed. MS was diagnosed according to both modified WHO and NCEP criteria using cut-off values for children. Abnormal glucose homeostasis was identified in 46.6% of the subjects. Fasting glucose levels for all subjects were less than 110 mg/dl and no subjects had type 2 diabetes. Overall, dyslipidemia was present in 42.9% and hypertension in 42.9% of the subjects. While 24% of the subjects were diagnosed as MS according to NCEP, a rate of 38.8% were diagnosed according to WHO-defined MS. There was a moderate agreement between NCEP and WHO guidelines. More children were diagnosed as MS based on the WHO guidelines. This may lead to better monitoring for these children and prevention of their chronic diseases in the future. Therefore, we recommend using WHO guidelines in the diagnosis of MS with a specific emphasis on definition of abnormal glucose homeostasis.
针对为成年人定义的代谢综合征（MS）诊断标准[美国国家胆固醇教育计划（NCEP）和世界卫生组织（WHO）]是否也可用于儿童，目前尚无共识。我们旨在使用WHO和NCEP指南比较肥胖儿童和青少年中代谢综合征的患病率。共评估了112名肥胖儿童和青少年。根据修改后的WHO和NCEP标准，使用儿童临界值诊断MS。46.6%的受试者存在葡萄糖稳态异常。所有受试者的空腹血糖水平均低于110mg/dl，且无受试者患有2型糖尿病。总体而言，42.9%的受试者存在血脂异常，42.9%的受试者患有高血压。根据NCEP，24%的受试者被诊断为MS；根据WHO定义的MS，诊断率为38.8%。NCEP和WHO指南之间存在中度一致性。基于WHO指南，更多儿童被诊断为MS。这可能会导致对这些儿童进行更好的监测，并在未来预防他们的慢性病。因此，我们建议在MS诊断中使用WHO指南，尤其要特别强调葡萄糖稳态异常的定义。
