Kristoffersen Jens, Sørensen Claus Havregaard, Nielsen Connie Thurøe, Stage Kurt Bjerregaard
Psykiatrisk Afdeling P, Odense Universitetshospital, DK-5000 Odense C.
Ugeskr Laeger. 2008 Nov 10;170(46):3753-5.
Psychotic depression is frequent among hospitalized patients diagnosed with major depression. Patients diagnosed with this type of depression display a number of specific characteristics. They have a higher risk of suicidal behaviour, they have a prolonged and more severe clinical picture and subsequently they have an increased risk of relapse. Studies show that monotherapy with antidepressants is more effective than antipsychotic monotherapy. Electroconvulsive therapy remains the most effective treatment, while tricyclic antidepressants in monotherapy are also effective. An antipsychotic drug can be added if no effect of monotherapeutic antidepressant treatment is observed within two to four weeks.
精神病性抑郁在被诊断为重度抑郁的住院患者中很常见。被诊断为这种类型抑郁的患者表现出一些特定特征。他们有更高的自杀行为风险,有更长且更严重的临床表现,随后复发风险增加。研究表明,抗抑郁药单药治疗比抗精神病药单药治疗更有效。电休克疗法仍然是最有效的治疗方法,而三环类抗抑郁药单药治疗也有效。如果在两到四周内未观察到抗抑郁药单药治疗的效果,可以加用一种抗精神病药物。