Bhatt M H, Snow B J, Martin W R, Peppard R, Calne D B
Department of Medicine, University Hospital, University of British Columbia, Vancouver, Canada.
Arch Neurol. 1991 Apr;48(4):389-91. doi: 10.1001/archneur.1991.00530160057013.
Positron emission tomography with 6-[18F]fluoro-L-dopa (6-FD) provides in vivo information on the function of nigrostriatal dopaminergic neurons. We used 6-FD and positron emission tomography to investigate the integrity of the nigrostriatal system in seven patients with progressive supranuclear palsy. All patients had axial hypertonia, vertical gaze palsy, and parkinsonian features. Dementia, pyramidal signs, and ataxia were seen in varying proportions. We analyzed the scans with a graphic method to calculate a steady-state 6-FD uptake rate constant for the whole striatum. Results were compared with those obtained in seven age-matched controls. As a group, the patients with progressive supranuclear palsy had reduced 6-FD uptake constants. The 6-FD uptake constant correlated inversely with the duration of the disease. Normal positron emission tographic findings in one patient with the shortest duration of symptoms suggests that in early progressive supranuclear palsy, parkinsonism may relate to dysfunction distal to the dopaminergic neurons.
用6-[18F]氟-L-多巴（6-FD）进行正电子发射断层扫描可提供有关黑质纹状体多巴胺能神经元功能的体内信息。我们使用6-FD和正电子发射断层扫描来研究7例进行性核上性麻痹患者黑质纹状体系统的完整性。所有患者均有轴向肌张力亢进、垂直凝视麻痹和帕金森样特征。不同比例的患者出现痴呆、锥体束征和共济失调。我们用图形方法分析扫描结果，以计算整个纹状体的稳态6-FD摄取速率常数。将结果与7名年龄匹配的对照者的结果进行比较。作为一个群体，进行性核上性麻痹患者的6-FD摄取常数降低。6-FD摄取常数与疾病持续时间呈负相关。一名症状持续时间最短的患者正电子发射断层扫描结果正常，这表明在早期进行性核上性麻痹中，帕金森病可能与多巴胺能神经元远端的功能障碍有关。
