Robinson David R, Gebhart G F
Department of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Mol Interv. 2008 Oct;8(5):242-53. doi: 10.1124/mi.8.5.9.
Most of what is written and believed about pain and nociceptors originates from studies of the "somatic" (non-visceral) sensory system. As a result, the unique features of visceral pain are often overlooked. In the clinic, the management of visceral pain is typically poor, and drugs that are used with some efficacy to treat somatic pain often present unwanted effects on the viscera. For these reasons, a better understanding of visceral sensory neurons-particularly visceral nociceptors-is required. This review provides evidence of functional, morphological, and biochemical differences between visceral and non-visceral afferents, with a focus on potential nociceptive roles, and also considers some of the potential mechanisms of visceral mechanosensation.
目前关于疼痛和伤害感受器的大多数著述及认知都源于对“躯体”（非内脏）感觉系统的研究。因此，内脏痛的独特特征常常被忽视。在临床上，内脏痛的治疗通常效果不佳，用于治疗躯体疼痛且有一定疗效的药物往往会对内脏产生不良影响。基于这些原因，我们需要更好地了解内脏感觉神经元，尤其是内脏伤害感受器。本综述提供了内脏和非内脏传入神经在功能、形态和生化方面差异的证据，重点关注潜在的伤害感受作用，同时也探讨了内脏机械感觉的一些潜在机制。
