一种与含克仑特罗的海洛因相关的新型神经肌肉综合征。
A novel neuromuscular syndrome associated with clenbuterol-tainted heroin.
作者信息
Manini Alex, Labinson Robert M, Kirrane Barbara, Hoffman Robert S, Rao Rama, Stajic Marina, Nelson Lewis S
机构信息
Department of Medical Toxicology, New York City Poison Center, New York, USA.
出版信息
Clin Toxicol (Phila). 2008 Dec;46(10):1088-92. doi: 10.1080/15563650802139948.
BACKGROUND
Clenbuterol is a potent, long-acting beta-adrenergic agonist that has been reported as an adulterant of heroin. We describe an atypical syndrome in five users of clenbuterol-tainted heroin.
METHODS
All cases were referred to a regional Poison Control Center. Urine and blood were analyzed using gas and liquid chromatography as well as mass spectrometry.
CASE SERIES
Five heroin users presented with a syndrome characterized by muscular spasm, tremor, hyperreflexia, and elevated serum creatine phosphokinase concentrations. All patients lacked findings of acute clenbuterol toxicity but tested positive for clenbuterol and negative for strychnine and a battery of common potential adulterants.
CONCLUSIONS
We report five cases of a novel neuromuscular syndrome in users of clenbuterol-adulterated heroin. It is unclear whether these reactions represent an atypical response to clenbuterol or another unidentified contaminant.
背景
克仑特罗是一种强效、长效的β-肾上腺素能激动剂，有报道称其为海洛因的掺假物。我们描述了五例使用受克仑特罗污染海洛因的患者出现的非典型综合征。
方法
所有病例均被转诊至地区毒物控制中心。使用气相色谱法、液相色谱法以及质谱分析法对尿液和血液进行分析。
病例系列
五名海洛因使用者出现了以肌肉痉挛、震颤、反射亢进以及血清肌酸磷酸激酶浓度升高为特征的综合征。所有患者均未表现出急性克仑特罗中毒的迹象，但克仑特罗检测呈阳性，而士的宁以及一系列常见潜在掺假物检测呈阴性。
结论
我们报告了五例使用掺有克仑特罗的海洛因的患者出现的新型神经肌肉综合征病例。尚不清楚这些反应是对克仑特罗的非典型反应还是由其他不明污染物所致。
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