Haffner Jérémie, Potiron Eric, Bouyé Sébastien, Puech Philippe, Leroy Xavier, Lemaitre Laurent, Villers Arnauld
Department of Urology, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Prostate. 2009 Feb 15;69(3):276-82. doi: 10.1002/pros.20881.
To describe the precise location of peripheral zone (PZ) prostate cancers at various stages of development and to demonstrate their pattern of intraprostatic spread from their site of origin.
PZ cancers defined as cancers located in peripheral zone (PZ) including the anterolateral part of PZ, were identified from radical prostatectomy specimens. PZ cancers morphometric histopathological study included largest surface area, volume and spatial distribution.
Out of 188 PZ cancers, 179 were <4 cm(3) and 168 <2 cm(3). PZ cancers were still confined to their zone of origin for volumes <2 cm(3). Between 2 and 4 cm(3), some cancers partially spread into the transition zone or anterior fibromuscular stroma. Sixty-four and 90% of PZ cancers <4 cm(3) were located in the lower and posterior half of the gland respectively. Ten percent were located in the anterior horn of PZ. Overall, non-index (second) cancers were located in the ipsi and contolateral side of the index cancer (largest) in 31% and 69% of cases, respectively. Cancers <2 cm(3) were confined to one lobe in 164 of 168 (98%) cases and not confined in 3 out of 11 (27%) cancers 2-4 cm(3). On vertical axis, only cancers >or=2 cm(3) involved both apex and base.
PZ cancers contours and locations are predictable and conform to histological zone boundaries if <2 cm(3) in volume. Knowledge of PZ cancers origin and pattern of spread in PZ are of importance for imaging diagnosis, guidance for biopsy and focal therapy.
描述外周带（PZ）前列腺癌在不同发展阶段的精确位置，并展示其从起源部位开始的前列腺内扩散模式。
从根治性前列腺切除术标本中识别出定义为位于外周带（PZ）包括PZ前外侧部分的癌症。PZ癌的形态计量组织病理学研究包括最大表面积、体积和空间分布。
在188例PZ癌中，179例体积<4 cm³，168例<2 cm³。体积<2 cm³的PZ癌仍局限于其起源区域。在2至4 cm³之间，一些癌症部分扩散至移行区或前部纤维肌基质。体积<4 cm³的PZ癌分别有64%和90%位于腺体的下半部和后半部。10%位于PZ的前角。总体而言，非索引（第二个）癌分别在31%和69%的病例中位于索引癌（最大）的同侧和对侧。168例体积<2 cm³的癌症中有164例（98%）局限于一个叶，而11例体积为2 - 4 cm³的癌症中有3例（27%）不局限于此。在垂直轴上，只有体积≥2 cm³的癌症同时累及尖部和底部。
如果体积<2 cm³，PZ癌的轮廓和位置是可预测的，并且符合组织学区域边界。了解PZ癌在PZ中的起源和扩散模式对于影像诊断、活检指导和聚焦治疗具有重要意义。
