Herold R, Feldmann A, Simon M, Tényi T, Kövér F, Nagy F, Varga E, Fekete S
Department of Psychiatry and Psychotherapy, University of Pécs, Pécs, Hungary.
Acta Psychiatr Scand. 2009 Mar;119(3):199-208. doi: 10.1111/j.1600-0447.2008.01297.x. Epub 2008 Nov 10.
We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia.
Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks.
Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole.
Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.
我们测试了精神分裂症早期患者心理理论（ToM）表现与大脑结构变化之间的关联。
将18例精神分裂症患者的基于体素的形态测量（VBM）数据与21名对照者的数据进行比较。通过计算机化的失礼（FP）任务评估ToM技能。
精神分裂症患者在FP任务中的表现明显比健康受试者差。VBM显示精神分裂症患者某些额叶、颞叶和皮质下区域的灰质密度显著降低。精神分裂症患者FP表现不佳与左侧眶额皮质和右侧颞极的灰质减少相关。
我们的数据表明，精神分裂症发病后不久，ToM表现不佳与左侧眶额皮质和右侧颞极的区域灰质减少之间存在关联。
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