Th2 极化的生物标志物可预测特应性皮炎患者的葡萄球菌定植情况。
Biomarkers of Th2 polarity are predictive of staphylococcal colonization in subjects with atopic dermatitis.
作者信息
Warner J A, McGirt L Y, Beck L A
机构信息
Department of Dermatology, Johns Hopkins Medical Institution, Baltimore, MD 21224, USA.
出版信息
Br J Dermatol. 2009 Jan;160(1):183-5. doi: 10.1111/j.1365-2133.2008.08905.x. Epub 2008 Oct 25.
BACKGROUND
Staphylococcal colonization of the skin is commonly observed in subjects with atopic dermatitis (AD) and correlates with disease severity. Little is known about whether the degree of T-helper 2 (Th2) polarity in these subjects can also affect the frequency of bacterial colonization in this disease.
OBJECTIVES
To determine if there is a correlation between markers of Th2 polarity [serum total IgE, eosinophilia and presence of another atopic disease (allergic rhinitis)] and skin colonization with Staphylococcus aureus in subjects with AD.
METHODS
A retrospective chart review was performed of an academic dermatology clinic focused on the treatment of AD with a single provider.
RESULTS
Staphylococcus aureus colonization was more commonly observed in subjects with AD who had peripheral eosinophilia, elevated serum IgE levels, and/or a history of or active allergic rhinitis.
CONCLUSIONS
Results suggest that Th2 polarity may enhance subjects' risk for bacterial colonization.
背景
在特应性皮炎（AD）患者中，皮肤葡萄球菌定植较为常见，且与疾病严重程度相关。关于这些患者中辅助性T细胞2（Th2）极化程度是否也会影响该疾病中细菌定植的频率，目前所知甚少。
目的
确定在AD患者中，Th2极化标志物[血清总IgE、嗜酸性粒细胞增多症以及另一种特应性疾病（过敏性鼻炎）的存在]与金黄色葡萄球菌皮肤定植之间是否存在相关性。
方法
对一家专注于由单一医生治疗AD的学术皮肤科诊所进行回顾性病历审查。
结果
在患有外周嗜酸性粒细胞增多症、血清IgE水平升高和/或有过敏性鼻炎病史或患有活动性过敏性鼻炎的AD患者中，更常观察到金黄色葡萄球菌定植。
结论
结果表明，Th2极化可能会增加患者细菌定植的风险。
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