Allocati Nerino, Federici Luca, Masulli Michele, Di Ilio Carmine
Dipartimento di Scienze Biomediche, Università G. d'Annunzio, Chieti, Italy.
FEBS J. 2009 Jan;276(1):58-75. doi: 10.1111/j.1742-4658.2008.06743.x.
Bacterial glutathione transferases (GSTs) are part of a superfamily of enzymes that play a key role in cellular detoxification. GSTs are widely distributed in prokaryotes and are grouped into several classes. Bacterial GSTs are implicated in a variety of distinct processes such as the biodegradation of xenobiotics, protection against chemical and oxidative stresses and antimicrobial drug resistance. In addition to their role in detoxification, bacterial GSTs are also involved in a variety of distinct metabolic processes such as the biotransformation of dichloromethane, the degradation of lignin and atrazine, and the reductive dechlorination of pentachlorophenol. This review article summarizes the current status of knowledge regarding the functional and structural properties of bacterial GSTs.
细菌谷胱甘肽转移酶（GSTs）是一类酶超家族的成员，在细胞解毒过程中发挥关键作用。GSTs广泛分布于原核生物中，并被分为几个类别。细菌GSTs参与多种不同的过程，如异生物质的生物降解、抵御化学和氧化应激以及抗微生物药物耐药性。除了在解毒中的作用外，细菌GSTs还参与多种不同的代谢过程，如二氯甲烷的生物转化、木质素和阿特拉津的降解以及五氯苯酚的还原脱氯。这篇综述文章总结了关于细菌GSTs功能和结构特性的当前知识状况。
