狒狒会阴区的黏液瘤性肿瘤。
Myxomatous neoplasms in the perineal region of baboons.
作者信息
Wallace Shannon M, Szabo Kathleen A, Schlabritz-Loutsevitch Natalia E, Dick Edward J, Blanchard Terrell W, Hubbard Gene B
机构信息
Department of Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
出版信息
J Med Primatol. 2008 Dec;37(6):261-70. doi: 10.1111/j.1600-0684.2008.00293.x.
BACKGROUND
In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years.
METHODS
We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants.
RESULTS
Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features.
CONCLUSION
Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms.
背景
在狒狒（Papio sp.）中，肿瘤最常累及造血系统，黏液瘤性肿瘤的记录很少。相比之下，女性在生育期会较频繁地在盆腔深部组织内形成黏液瘤性肿块。
方法
我们在一个研究机构中对12只雌性狒狒的黏液性会阴肿块进行了回顾性鉴定和检查，并将其组织病理学、免疫组织化学和电子显微镜特征与其人类病变进行了比较。
结果
我们的结果表明，这些黏液瘤性肿瘤在人类和非人类灵长类动物中具有共同特征。
结论
可能需要进一步研究，尤其是分子遗传学分析，以确定狒狒是否为黏液性会阴肿瘤的真正动物模型。
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