Owston M A, LaRue M K, Dick E J, Ambrus A, Porter B F
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
J Med Primatol. 2016 Apr;45(2):85-91. doi: 10.1111/jmp.12210. Epub 2016 Feb 22.
Pancreatic neuroendocrine tumors (PNETs) are rare in nonhuman primates and in humans.
Twenty-one PNETs from twelve female baboons (Papio spp.) from the Southwest National Primate Research Center were evaluated using histopathology and immunohistochemistry.
Histologically, all tumors were benign and had neuroendocrine packeting. Immunohistochemical staining for synaptophysin and chromogranin was positive in all tumors evaluated (17/17). Insulin was positive in 16 of 21 tumors. Somatostatin was positive in 9 of 20 tumors. Multifocal staining for glucagon and pancreatic polypeptide was evident in a minority of tumors (6/20 and 2/17, respectively). Gastrin and vasoactive intestinal peptide were negative in all tumors evaluated. Nine tumors expressed more than one hormone marker.
This is the first detailed pathologic study of pancreatic endocrine tumors in the baboon. The findings suggest that these tumors are generally benign and have similar morphologic and immunohistochemical features as those described in people, including the ability to express multiple hormones.
胰腺神经内分泌肿瘤（PNETs）在非人灵长类动物和人类中均较为罕见。
对来自西南国家灵长类动物研究中心的12只雌性狒狒（狒属）的21个PNETs进行了组织病理学和免疫组织化学评估。
组织学上，所有肿瘤均为良性，具有神经内分泌包块。在所评估的所有肿瘤（17/17）中，突触素和嗜铬粒蛋白免疫组织化学染色均呈阳性。胰岛素在21个肿瘤中的16个呈阳性。生长抑素在20个肿瘤中的9个呈阳性。少数肿瘤（分别为6/20和2/17）中可见胰高血糖素和胰多肽的多灶性染色。在所评估的所有肿瘤中，胃泌素和血管活性肠肽均为阴性。9个肿瘤表达了不止一种激素标志物。
这是对狒狒胰腺内分泌肿瘤的首次详细病理学研究。研究结果表明，这些肿瘤通常为良性，具有与人类所描述的相似的形态学和免疫组织化学特征，包括表达多种激素的能力。
