Effects of gaba, gabob and some anticonvulsant drugs on dibutyryl cyclic AMP evoked seizures.

The present experiments were undertaken to study the possible effects of Gaba, Gabob, phenobarbitone, diphenylhydantoin, and diazepam given systemically on convulsant activity evoked in chicks by intrahypothalamic injection of dibutyryl cyclic AMP (cAMP). Diphenylhydantoin and phenobarbitone antagonized the effect of dibutyryl cAMP but unfortunately the effects of Gaba and Gabob were complicated by osmotic effects. Diazepam, an anticonvulsant benzodiazepine, did not affect dibutyryl cAMP-induced electrocortical spiking. The dibutyryl cAMP-induced syndrome seems to be of limited value as a model for assessing the activity of anticonvulsant drugs are present.