Ruan Sheng-Yuan, Chien Jung-Yien, Hsueh Po-Ren
Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan, ROC.
Departments of Internal Medicine and Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
J Med Microbiol. 2008 Dec;57(Pt 12):1585-1587. doi: 10.1099/jmm.0.2008/003202-0.
Candiduria is an increasingly common condition, and the lack of effective antifungal treatment in many cases has raised great concern. We report a case of persistent Candida parapsilosis funguria associated with urinary tract instrumentation. Molecular typing suggested that during a 7 year period the C. parapsilosis isolates were all the same strain. Prolonged antifungal therapy and regular catheter replacement failed to eradicate the funguria, but improved urinary symptoms and pyuria. The antifungal susceptibility pattern did not significantly change during the clinical course despite repeated exposure to fluconazole.
念珠菌尿症是一种日益常见的病症，许多病例中缺乏有效的抗真菌治疗引起了极大关注。我们报告一例与尿路器械操作相关的持续性近平滑念珠菌真菌尿症病例。分子分型表明，在7年期间，近平滑念珠菌分离株均为同一菌株。延长抗真菌治疗时间和定期更换导管未能根除真菌尿，但改善了尿路症状和脓尿。尽管反复接触氟康唑，但在临床过程中抗真菌药敏模式没有明显变化。
