Zepf Florian Daniel, Holtmann M, Stadler C, Wöckel L, Poustka F
Department of Child and Adolescent Psychiatry and Psychotherapy, Goethe University of Frankfurt am Main, Deutschordenstr, Frankfurt, Germany.
J Neural Transm (Vienna). 2009 Jan;116(1):105-8. doi: 10.1007/s00702-008-0146-0. Epub 2008 Nov 19.
Reduced mean heart rate (HR) was shown to be a biophysiological marker for aggression, which in turn was proven to be related to changed serotonergic neurotransmission. A total of 16 ADHD-diagnosed boys were subjected to rapid tryptophan depletion (RTD) and a placebo in a double-blind within-subject crossover-design. Mean HR was assessed under RTD/placebo. Low impulsive patients behaving aggressively under RTD showed a lowered HR under RTD versus placebo. Diminished 5-HT functioning was associated with lowered HR and aggressive behaviour.
平均心率降低被证明是攻击行为的一种生物生理标志物，而攻击行为又被证明与血清素能神经传递的改变有关。共有16名被诊断为注意力缺陷多动障碍的男孩参与了一项双盲的受试者内交叉设计实验，分别接受快速色氨酸耗竭（RTD）和安慰剂治疗。在RTD/安慰剂治疗下评估平均心率。在RTD期间表现出攻击行为的低冲动性患者，与接受安慰剂相比，在RTD期间心率降低。5-羟色胺功能的减弱与心率降低和攻击行为有关。
