脑源性神经营养因子基因：情绪障碍和精神分裂症中的功能性缬氨酸66蛋氨酸多态性
BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia.
作者信息
Rybakowski Janusz K
机构信息
Department of Adult Psychiatry, Poznan University of Medical Science, Szpitalna 27/33, 60-572 Poznan, Poland.
出版信息
Pharmacogenomics. 2008 Nov;9(11):1589-93. doi: 10.2217/14622416.9.11.1589.
The brain-derived neurotrophic factor (BDNF) gene has become a candidate gene for molecular-genetic studies of mood disorders and schizophrenia, and also for pharmacogenomics of drugs used in the treatment of these conditions, such as mood-stabilizers in bipolar mood disorder, antidepressants in depression, and antipsychotics in schizophrenia. It has been demonstrated that the functional Val66Met polymorphism of the gene can be associated with a number of clinical and pharmacological phenomena in these illnesses.
脑源性神经营养因子（BDNF）基因已成为情绪障碍和精神分裂症分子遗传学研究的候选基因，也是这些疾病治疗所用药物（如双相情感障碍中的心境稳定剂、抑郁症中的抗抑郁药以及精神分裂症中的抗精神病药）药物基因组学研究的候选基因。已经证实，该基因的功能性Val66Met多态性可能与这些疾病中的许多临床和药理学现象相关。
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