从金钟花叶片中分离得到的连翘酯苷对去甲肾上腺素诱导的主动脉收缩的血管舒张作用。

Vasorelaxant effects of forsythide isolated from the leaves of Forsythia viridissima on NE-induced aortal contraction.

作者信息

Iizuka T, Sakai H, Moriyama H, Suto N, Nagai M, Bagchi D

机构信息

Laboratory of Pharmacognosy, Yokohama College of Pharmacy, Matano-cho 601, Tozuka-ku, Yokohama, Kanagawa 245-0066, Japan.

出版信息

Phytomedicine. 2009 Apr;16(4):386-90. doi: 10.1016/j.phymed.2008.09.011. Epub 2008 Nov 18.

DOI:10.1016/j.phymed.2008.09.011

PMID:19019645

Abstract

Forsythide (F1) isolated from the leaves of Forsythia viridissima (Oleaceae) showed vasorelaxant effects on norepinephrine (NE)-induced contraction of rat aorta with or without endothelium. This compound did not affect contraction induced by high concentration potassium (60 mM K(+)) and phorbol 12,13-diacetate, but inhibited NE-induced contraction in the presence of nicardipine. These results demonstrated the inhibitory effects of F1 on NE-induced vasocontraction presumably due to decrease of calcium influx from extracellular area, which was induced by NE.

摘要

从金钟花（木犀科）叶子中分离得到的连翘酯苷（F1）对去甲肾上腺素（NE）诱导的有或无内皮的大鼠主动脉收缩均有血管舒张作用。该化合物不影响高浓度钾（60 mM K⁺）和佛波醇12,13 - 二乙酸酯诱导的收缩，但在尼卡地平存在的情况下抑制NE诱导的收缩。这些结果表明F1对NE诱导的血管收缩具有抑制作用，推测这是由于NE诱导的细胞外钙内流减少所致。