肠道细菌、代谢产物和炎症分子之间的诱导相互作用对改善自然皮肤老化的影响
The Effect of Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging.
作者信息
Hiramoto Keiichi, Kubo Sayaka, Tsuji Keiko, Sugiyama Daijiro, Iizuka Yasutaka, Hamano Hideo
机构信息
Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan.
Research Department, Daiichi Sankyo Healthcare Co., Ltd., Tokyo 140-8170, Japan.
出版信息
Dermatopathology (Basel). 2023 Sep 28;10(4):287-302. doi: 10.3390/dermatopathology10040037.
BACKGROUND
Lactic acid bacteria consumption serves several health benefits to humans. However, their effect on natural skin aging is still unclear.
METHODS
This study examined the effects of skin naturalization (particularly skin drying) by administering a spore-bearing lactic acid bacteria () in mice for 2 years.
RESULTS
administration improved the natural skin of mice and significantly increased proportions of the genera and , among other intestinal bacteria. As metabolites, increases in nicotinic acid, putrescin, and pantothenic acid levels and a decrease in choline levels were observed. Increased hyaluronic acid, interleukin-10, and M2 macrophage levels indicate aging-related molecules in the skin. Intestinal permeability was also suppressed. Thus, these changes together improved natural skin aging.
CONCLUSIONS
This study revealed that administration improved the natural skin aging in mice. This enhancement might be induced by the interaction of alterations in intestinal flora, metabolites, or inflammatory substances.
背景
食用乳酸菌对人类有多种健康益处。然而，它们对皮肤自然老化的影响仍不清楚。
方法
本研究通过在小鼠中施用产芽孢乳酸菌两年，研究皮肤自然化（特别是皮肤干燥）的影响。
结果
施用改善了小鼠的皮肤自然状态，并显著增加了包括和在内的肠道细菌属的比例。作为代谢产物，观察到烟酸、腐胺和泛酸水平升高，胆碱水平降低。透明质酸、白细胞介素-10和M2巨噬细胞水平升高表明皮肤中与衰老相关的分子。肠道通透性也受到抑制。因此，这些变化共同改善了皮肤自然老化。
结论
本研究表明，施用改善了小鼠的皮肤自然老化。这种改善可能是由肠道菌群、代谢产物或炎症物质的变化相互作用引起的。
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