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Efficient nuclear export of herpes simplex virus 1 transcripts requires both RNA binding by ICP27 and ICP27 interaction with TAP/NXF1.单纯疱疹病毒1型转录本的高效核输出既需要ICP27与RNA结合，也需要ICP27与TAP/NXF1相互作用。
J Virol. 2009 Feb;83(3):1184-92. doi: 10.1128/JVI.02010-08. Epub 2008 Nov 19.
2
The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.细胞RNA输出受体TAP/NXF1是单纯疱疹病毒1型RNA由ICP27介导输出所必需的，但转录-输出衔接蛋白复合体Aly/REF似乎并非必需。
J Virol. 2009 Jul;83(13):6335-46. doi: 10.1128/JVI.00375-09. Epub 2009 Apr 15.
3
ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export.ICP27招募Aly/REF至1型单纯疱疹病毒转录位点，但不招募TAP/NXF1，尽管TAP/NXF1是ICP27输出所必需的。
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4
ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA.ICP27 磷酸化位点突变体与细胞输出因子 Aly/REF 和 TAP/NXF1 的功能相互作用发生改变，但仍能结合单纯疱疹病毒 1 RNA。
J Virol. 2010 Mar;84(5):2212-22. doi: 10.1128/JVI.01388-09. Epub 2009 Dec 16.
5
The interaction of the cellular export adaptor protein Aly/REF with ICP27 contributes to the efficiency of herpes simplex virus 1 mRNA export.细胞输出衔接蛋白 Aly/REF 与 ICP27 的相互作用有助于单纯疱疹病毒 1 mRNA 的输出效率。
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6
Head-to-tail intramolecular interaction of herpes simplex virus type 1 regulatory protein ICP27 is important for its interaction with cellular mRNA export receptor TAP/NXF1.单纯疱疹病毒 1 型调控蛋白 ICP27 的头对头分子内相互作用对于其与细胞 mRNA 输出受体 TAP/NXF1 的相互作用很重要。
mBio. 2010 Nov 9;1(5):e00268-10. doi: 10.1128/mBio.00268-10.
7
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway.单纯疱疹病毒ICP27蛋白为病毒mRNA提供进入细胞mRNA输出途径的机会。
EMBO J. 2001 Oct 15;20(20):5769-78. doi: 10.1093/emboj/20.20.5769.
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SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs.SR 蛋白 SRp20 和 9G8 有助于单纯疱疹病毒 1 mRNAs 的有效输出。
Virology. 2010 Jun 5;401(2):155-64. doi: 10.1016/j.virol.2010.02.023. Epub 2010 Mar 12.
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Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways.单纯疱疹病毒 ICP27 蛋白通过 Nup62 与核孔复合物直接相互作用，抑制宿主核质转运途径。
J Biol Chem. 2012 Apr 6;287(15):12277-92. doi: 10.1074/jbc.M111.331777. Epub 2012 Feb 14.
10
ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway.ICP27与RNA输出因子Aly/REF相互作用，引导单纯疱疹病毒1型无内含子mRNA进入TAP输出途径。
J Virol. 2002 Dec;76(24):12877-89. doi: 10.1128/jvi.76.24.12877-12889.2002.

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Herpes Simplex Virus-1 ICP27 Nuclear Export Signal Mutants Exhibit Cell Type-Dependent Deficits in Replication and ICP4 Expression.单纯疱疹病毒-1 ICP27 核输出信号突变体在复制和 ICP4 表达方面表现出细胞类型依赖性缺陷。
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Identification of cellular proteins associated with human cytomegalovirus (HCMV) DNA replication suggests novel cellular and viral interactions.鉴定与人类巨细胞病毒（HCMV）DNA 复制相关的细胞蛋白，提示了新的细胞和病毒相互作用。
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Stress Induced Transcription Factors Transactivate the Herpes Simplex Virus 1 Infected Cell Protein 27 (ICP27) Transcriptional Enhancer.应激诱导转录因子反式激活单纯疱疹病毒 1 感染细胞蛋白 27（ICP27）转录增强子。
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Widespread remodeling of the mA RNA-modification landscape by a viral regulator of RNA processing and export.病毒调节 RNA 加工和输出对 mA RNA 修饰图谱的广泛重塑。
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Strength in Diversity: Nuclear Export of Viral RNAs.多样性中的力量：病毒 RNA 的核输出。
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Intron retention in viruses and cellular genes: Detention, border controls and passports.病毒和细胞基因中的内含子保留：拘留、边境管制和护照。
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Characterization of Elements Regulating the Nuclear-to-Cytoplasmic Translocation of ICP0 in Late Herpes Simplex Virus 1 Infection.单纯疱疹病毒1型晚期感染中调控ICP0核质转运的元件的特征分析
J Virol. 2018 Jan 2;92(2). doi: 10.1128/JVI.01673-17. Print 2018 Jan 15.

本文引用的文献

1
Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.HSV-1转录位点周边热休克蛋白70（Hsc70）聚集体的形成需要ICP27。
PLoS One. 2008 Jan 30;3(1):e1491. doi: 10.1371/journal.pone.0001491.
2
Human mRNA export machinery recruited to the 5' end of mRNA.人类信使核糖核酸（mRNA）输出机制被招募至mRNA的5'端。
Cell. 2006 Dec 29;127(7):1389-400. doi: 10.1016/j.cell.2006.10.044.
3
ICP27 interacts with the C-terminal domain of RNA polymerase II and facilitates its recruitment to herpes simplex virus 1 transcription sites, where it undergoes proteasomal degradation during infection.ICP27与RNA聚合酶II的C末端结构域相互作用，并促进其被招募到单纯疱疹病毒1转录位点，在感染过程中它在该位点经历蛋白酶体降解。
J Virol. 2006 Apr;80(7):3567-81. doi: 10.1128/JVI.80.7.3567-3581.2006.
4
The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.人巨细胞病毒的UL69反式激活蛋白与DEXD/H盒RNA解旋酶UAP56相互作用，以促进未剪接RNA的细胞质积累。
Mol Cell Biol. 2006 Mar;26(5):1631-43. doi: 10.1128/MCB.26.5.1631-1643.2006.
5
Recruitment of the human TREX complex to mRNA during splicing.剪接过程中人类 TREX 复合物与 mRNA 的结合。
Genes Dev. 2005 Jul 1;19(13):1512-7. doi: 10.1101/gad.1302205.
6
ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export.ICP27招募Aly/REF至1型单纯疱疹病毒转录位点，但不招募TAP/NXF1，尽管TAP/NXF1是ICP27输出所必需的。
J Virol. 2005 Apr;79(7):3949-61. doi: 10.1128/JVI.79.7.3949-3961.2005.
7
Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo.单纯疱疹病毒1型ICP27转录本的早期即刻表达对于体外或体内的高效复制并不关键。
J Virol. 2004 Oct;78(19):10470-8. doi: 10.1128/JVI.78.19.10470-10478.2004.
8
The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor.具有进化保守性的卡波西肉瘤相关疱疹病毒ORF57蛋白与REF蛋白相互作用，并作为一种RNA输出因子发挥作用。
J Biol Chem. 2004 Jul 30;279(31):33001-11. doi: 10.1074/jbc.M313008200. Epub 2004 May 20.
9
In vivo recruitment of exon junction complex proteins to transcription sites in mammalian cell nuclei.体内外显子连接复合体蛋白在哺乳动物细胞核转录位点的募集。
RNA. 2004 Apr;10(4):622-33. doi: 10.1261/rna.5258504.
10
Splicing enhances translation in mammalian cells: an additional function of the exon junction complex.剪接增强哺乳动物细胞中的翻译：外显子连接复合体的额外功能。
Genes Dev. 2004 Jan 15;18(2):210-22. doi: 10.1101/gad.1163204.

单纯疱疹病毒1型转录本的高效核输出既需要ICP27与RNA结合，也需要ICP27与TAP/NXF1相互作用。

Efficient nuclear export of herpes simplex virus 1 transcripts requires both RNA binding by ICP27 and ICP27 interaction with TAP/NXF1.

作者信息

Johnson Lisa A, Sandri-Goldin Rozanne M

机构信息

Department of Microbiology and Molecular Genetics, School of Medicine, Medical Sciences, B240, University of California, Irvine, CA 92697-4025, USA.

出版信息

J Virol. 2009 Feb;83(3):1184-92. doi: 10.1128/JVI.02010-08. Epub 2008 Nov 19.

DOI:10.1128/JVI.02010-08
PMID:19019956
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2620904/
Abstract

Herpes simplex virus 1 (HSV-1) regulatory protein ICP27 has been reported to bind viral RNA and to interact with the nuclear export adaptor Aly/REF and the major cellular mRNA nuclear export receptor TAP/NXF1. Using in situ hybridization and in vitro export assays, we show here that poly(A)(+) RNA was retained in the nucleus of cells infected with viral ICP27 mutants that either cannot bind RNA or that do not interact with TAP/NXF1. Microarray analysis of nuclear and cytoplasmic RNA fractions demonstrated that efficient export of the majority of viral transcripts requires that ICP27 be able to bind RNA and to interact with TAP/NXF1. We conclude that ICP27 is the major export adaptor for HSV-1 mRNA and that it links bound transcripts to the TAP/NXF1 export receptor.

摘要

据报道，单纯疱疹病毒1型（HSV-1）调节蛋白ICP27可结合病毒RNA，并与核输出衔接蛋白Aly/REF以及主要的细胞mRNA核输出受体TAP/NXF1相互作用。通过原位杂交和体外输出分析，我们在此表明，聚腺苷酸（poly(A)）(+) RNA保留在感染了病毒ICP27突变体的细胞核中，这些突变体要么无法结合RNA，要么不与TAP/NXF1相互作用。对核RNA和细胞质RNA组分进行的微阵列分析表明，大多数病毒转录本的有效输出要求ICP27能够结合RNA并与TAP/NXF1相互作用。我们得出结论，ICP27是HSV-1 mRNA的主要输出衔接蛋白，并且它将结合的转录本与TAP/NXF1输出受体相连。