Woo Michael, O'Connor Michael, Yuan Chun-Su, Moss Jonathan
Department Anesthesia and Critical Care, The University of Chicago, 5841 S. Maryland Ave., MC 4028, Chicago, IL 60637, USA.
Anesth Analg. 2008 Dec;107(6):1965-7. doi: 10.1213/ane.0b013e31818556d3.
Peripheral-acting mu opiate receptor antagonists have been extensively studied for the treatment of opiate-induced constipation in advanced illness for the prophylaxis of postoperative ileus. We document the first intensive care patient to receive methylnaltrexone in an attempt to facilitate enteral nutrition. Gastric residuals markedly decreased and enteral feeding increased after administration of i.v. methylnaltrexone. The patient's ileus resolved coincident with the first injection.
外周作用的μ阿片受体拮抗剂已被广泛研究用于治疗晚期疾病中阿片类药物引起的便秘以及预防术后肠梗阻。我们记录了首例接受甲基纳曲酮以促进肠内营养的重症监护患者。静脉注射甲基纳曲酮后，胃残余量显著减少，肠内喂养量增加。患者的肠梗阻在首次注射后随之缓解。
