硫酸软骨素和硫酸角质素几乎是等构的。
Chondroitin sulphate and keratan sulphate are almost isosteric.
作者信息
Scott J E
机构信息
Chemical Morphology, Cell and Structural Biology, University of Manchester, U.K.
出版信息
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):267-8. doi: 10.1042/bj2750267.
Abstract
Keratan sulphate and chondroitin sulphate (KS and CS) in the 2-fold helical configurations that are prevalent in solution are of very similar tacticity. The chiral centres, anionic sites and hydrophobic patches are in identical conformations. Only the position of the acetamido group varies from CS to KS, but part of its intramolecular H-bonding potential in CS is retained in KS. The formation of tertiary aggregates, observed in vitro and in tissues, is explicable on these bases. The proposal that KS may be a functional substitute for CS [Scott & Haigh (1988) J. Anat. 158, 95-108] under low-O2 conditions is relevant.
摘要
溶液中普遍存在的呈双螺旋结构的硫酸角质素和硫酸软骨素（KS和CS）具有非常相似的立构规整性。手性中心、阴离子位点和疏水区域具有相同的构象。只有乙酰氨基的位置在CS和KS之间有所不同，但CS中其部分分子内氢键潜力在KS中得以保留。在体外和组织中观察到的三级聚集体的形成基于这些原因是可以解释的。关于在低氧条件下KS可能是CS的功能替代物的提议[斯科特和黑格（1988年）《解剖学杂志》158卷，95 - 108页]是有意义的。
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Biochem J. 1982 Oct 1;207(1):139-44. doi: 10.1042/bj2070139.
3
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