Mignini Fiorenzo, Tomassoni Daniele, Traini Enea, Streccioni Valentino
Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Università di Camerino, Camerino, Italy.
Clin Exp Hypertens. 2008 Nov;30(8):776-84. doi: 10.1080/07420520802572341.
The present work has used controlled conditions to study how physical activity and stress affect oxidant and anti-oxidant systems in a human model. Stress test consisting of one hour exercise at a cycloergometer with intensity over the 75% of the maximal cardiac frequency was followed by non-significant changes of malonyldialdehyde, assayed as a marker of lipid peroxidation, and by an increase of erythrocyte catalase and plasma and erythrocyte glutathione peroxidase after the test. These findings suggest that antioxidant response is broadly versatile and adaptable, and that physical activity may prevent extended cellular damage with consequent flogosis. Hence, controlled physical exercise may contribute to protect target organs, including cardiovascular systems, against oxidative stress.
本研究采用可控条件，在人体模型中研究身体活动和压力如何影响氧化和抗氧化系统。压力测试包括在蹬车测力计上进行一小时运动，强度超过最大心率的75%，测试后丙二醛（作为脂质过氧化的标志物进行检测）无显著变化，而红细胞过氧化氢酶、血浆和红细胞谷胱甘肽过氧化物酶增加。这些发现表明抗氧化反应具有广泛的通用性和适应性，身体活动可能预防因炎症反应导致的细胞广泛损伤。因此，有控制的体育锻炼可能有助于保护包括心血管系统在内的靶器官免受氧化应激的影响。
