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1
Constitutive mutations in the controlling site region of the araBAD operon of Escherichia coli B/r that decrease sensitivity to catabolite repression.大肠杆菌B/r的araBAD操纵子控制位点区域中的组成型突变，降低了对分解代谢物阻遏的敏感性。
J Bacteriol. 1977 Feb;129(2):948-58. doi: 10.1128/jb.129.2.948-958.1977.
2
Mutations affecting catabolite repression of the L-arabinose regulon in Escherichia coli B/r.影响大肠杆菌B/r中L-阿拉伯糖操纵子分解代谢阻遏的突变
J Bacteriol. 1976 Jun;126(3):1119-31. doi: 10.1128/jb.126.3.1119-1131.1976.
3
Deoxyribonucleic acid sequence of araBAD promoter mutants of Escherichia coli.大肠杆菌araBAD启动子突变体的脱氧核糖核酸序列
J Bacteriol. 1980 May;142(2):659-67. doi: 10.1128/jb.142.2.659-667.1980.
4
Dominance relationships among mutant alleles of regulatory gene araC in the Escherichia coli B/R L-arabinose operon.大肠杆菌B/R L-阿拉伯糖操纵子中调控基因araC突变等位基因之间的显性关系。
J Bacteriol. 1986 Nov;168(2):999-1001. doi: 10.1128/jb.168.2.999-1001.1986.
5
Mutations in the L-arabinose operon of Escherichia coli B-r that result in hypersensitivity to catabolite repression.大肠杆菌B-r的L-阿拉伯糖操纵子中的突变导致对分解代谢物阻遏的超敏反应。
J Bacteriol. 1974 Feb;117(2):417-21. doi: 10.1128/jb.117.2.417-421.1974.
6
Regulatory properties of araC(c) mutants in the L-arabinose operon of escherichia coliB/r.大肠杆菌B/r中L-阿拉伯糖操纵子中araC(c)突变体的调控特性
J Bacteriol. 1978 Jan;133(1):178-84. doi: 10.1128/jb.133.1.178-184.1978.
7
Hypersensitivity to catabolite repression in the L-arabinose operon of Escherichia coli B/r is trans acting.大肠杆菌B/r的L-阿拉伯糖操纵子中对分解代谢物阻遏的超敏反应是反式作用的。
J Bacteriol. 1976 May;126(2):1014-6. doi: 10.1128/jb.126.2.1014-1016.1976.
8
The site for catabolite deactivation in the L-arabinose BAD operon in Escherichia coli B/r.大肠杆菌B/r中L-阿拉伯糖BAD操纵子中分解代谢物失活的位点。
Arch Microbiol. 1976 Oct 11;110(1):135-43. doi: 10.1007/BF00416978.
9
Hyperinducibility as a result of mutation in structural genes and self-catabolite repression in the ara operon.由于结构基因突变导致的超诱导性以及阿拉伯糖操纵子中的自我分解代谢物阻遏。
J Bacteriol. 1971 Jul;107(1):34-52. doi: 10.1128/jb.107.1.34-52.1971.
10
Interaction between mutant alleles of araC of the Escherichia coli B/r L-arabinose operon.大肠杆菌B/r L-阿拉伯糖操纵子araC突变等位基因之间的相互作用。
J Bacteriol. 1979 Sep;139(3):1085-8. doi: 10.1128/jb.139.3.1085-1088.1979.

引用本文的文献

1
AraC Functional Suppressors of Mutations in the C-Terminal Domain of the RpoA Subunit of the RNA Polymerase.RNA聚合酶RpoA亚基C末端结构域突变的AraC功能抑制子
Microorganisms. 2024 Sep 23;12(9):1928. doi: 10.3390/microorganisms12091928.
2
Linkage map of Escherichia coli K-12, edition 6.大肠杆菌K-12连锁图谱，第6版。
Microbiol Rev. 1980 Mar;44(1):1-56. doi: 10.1128/mr.44.1.1-56.1980.
3
Functional limits of the araIc promoter suggest an additional regulatory site for araBAD expression.araIc启动子的功能限制表明了araBAD表达的一个额外调控位点。
J Bacteriol. 1984 Apr;158(1):141-7. doi: 10.1128/jb.158.1.141-147.1984.
4
Catabolite repression during single and multiple induction in Escherichia coli.大肠杆菌单次和多次诱导过程中的分解代谢物阻遏
Folia Microbiol (Praha). 1981;26(1):1-7. doi: 10.1007/BF02927215.
5
Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein.缺乏环腺苷酸受体蛋白的大肠杆菌突变体中的分解代谢物阻遏
Proc Natl Acad Sci U S A. 1980 Oct;77(10):5799-801. doi: 10.1073/pnas.77.10.5799.
6
Deoxyribonucleic acid sequence of araBAD promoter mutants of Escherichia coli.大肠杆菌araBAD启动子突变体的脱氧核糖核酸序列
J Bacteriol. 1980 May;142(2):659-67. doi: 10.1128/jb.142.2.659-667.1980.
7
The DNA loop model for ara repression: AraC protein occupies the proposed loop sites in vivo and repression-negative mutations lie in these same sites.阿拉伯糖阻遏的DNA环模型：阿拉伯糖C蛋白在体内占据了所提出的环位点，且阻遏阴性突变位于这些相同位点。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3654-8. doi: 10.1073/pnas.83.11.3654.
8
Sequence elements in the Escherichia coli araFGH promoter.大肠杆菌araFGH启动子中的序列元件。
J Bacteriol. 1992 Nov;174(21):6862-71. doi: 10.1128/jb.174.21.6862-6871.1992.
9
Interaction between mutant alleles of araC of the Escherichia coli B/r L-arabinose operon.大肠杆菌B/r L-阿拉伯糖操纵子araC突变等位基因之间的相互作用。
J Bacteriol. 1979 Sep;139(3):1085-8. doi: 10.1128/jb.139.3.1085-1088.1979.
10
DNA sequence of the araBAD promoter in Escherichia coli B/r.大肠杆菌B/r中araBAD启动子的DNA序列。
Proc Natl Acad Sci U S A. 1978 Oct;75(10):4724-8. doi: 10.1073/pnas.75.10.4724.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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2
L-ARABINOSE NEGATIVE MUTANTS OF THE L-RIBULOKINASE STRUCTURAL GENE AFFECTING THE LEVELS OF L-ARABINOSE ISOMERASE IN ESCHERICHIA COLI.影响大肠杆菌中L-阿拉伯糖异构酶水平的L-核糖激酶结构基因的L-阿拉伯糖阴性突变体
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3
Determination of the order of mutational sites governing L-arabinose utilization in Escherichia coli B/r bv transduction with phage Plbt.用噬菌体Plbt对大肠杆菌B/r bv进行转导时，确定控制L-阿拉伯糖利用的突变位点顺序
Virology. 1959 Nov;9:314-31. doi: 10.1016/0042-6822(59)90125-4.
4
Enzymatic characterization of 17 L-arabinose negative mutants of Escherichia coli.大肠杆菌17个L-阿拉伯糖阴性突变体的酶学特性分析
J Bacteriol. 1961 Jun;81(6):996-1006. doi: 10.1128/jb.81.6.996-1006.1961.
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Further evidence for positive control of the L-arabinose system by gene araC.基因araC对L-阿拉伯糖系统进行正向调控的进一步证据。
J Mol Biol. 1967 May 14;25(3):443-54. doi: 10.1016/0022-2836(67)90197-0.
6
Positive control of enzyme synthesis by gene C in the L-arabinose system.在L-阿拉伯糖系统中，基因C对酶合成的正调控。
J Bacteriol. 1965 Oct;90(4):946-57. doi: 10.1128/jb.90.4.946-957.1965.
7
Initiator constitutive mutants of the L-arabinose operon (OIBAD) of Escherichia coli B/r.大肠杆菌B/r的L-阿拉伯糖操纵子（OIBAD）的起始组成型突变体。
Genetics. 1971 Nov;69(3):289-302. doi: 10.1093/genetics/69.3.289.
8
An analysis of "revertants" of a deletion mutant in the C gene of the L-arabinose gene complex in Escherichia coli B-r: isolation of initiator constitutive mutants (Ic).大肠杆菌B-r中L-阿拉伯糖基因复合体C基因缺失突变体“回复体”的分析：起始组成型突变体（Ic）的分离
J Mol Biol. 1969 Jul 28;43(2):281-98. doi: 10.1016/0022-2836(69)90268-x.
9
The L-arabinose operon in Escherichia coli B-r: a genetic demonstration of two functional states of the product of a regulator gene.大肠杆菌B-r中的L-阿拉伯糖操纵子：调节基因产物两种功能状态的遗传学证明。
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1100-7. doi: 10.1073/pnas.62.4.1100.
10
Arabinose-leucine deletion mutants of Escherichia coli B-r.大肠杆菌B-r的阿拉伯糖-亮氨酸缺失突变体
J Bacteriol. 1969 Jun;98(3):1159-69. doi: 10.1128/jb.98.3.1159-1169.1969.

大肠杆菌B/r的araBAD操纵子控制位点区域中的组成型突变，降低了对分解代谢物阻遏的敏感性。

Constitutive mutations in the controlling site region of the araBAD operon of Escherichia coli B/r that decrease sensitivity to catabolite repression.

作者信息

Colomé J, Wilcox G, Englesberg E

出版信息

J Bacteriol. 1977 Feb;129(2):948-58. doi: 10.1128/jb.129.2.948-958.1977.

DOI:10.1128/jb.129.2.948-958.1977
PMID:190211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC235033/
Abstract

Strains of Escherichia coli B/r containing a deletion of the regulatory gene araC are Ara-. Slow-growing revertants of these strains were isolated and designated aralc because they contain a second mutation in a controlling site, aral, that allows for a low level of constitutive expression of the araBAD operon (Englesbert et al., 1969). We mutagenized aralc delta C strains and selected mutants that grow faster in mineral L-arabinose medium. The new mutations, called araXc, map very close to the original aralc mutations and are in the controlling site region between araB and araC. The aralcXc delta C strains have a higher constitutive level of expression of the araBAD operon than the aralc delta C parents. The araXc mutations are cis acting and decrease the araBAD operon's sensitivity to catabolite repression. The araBAD operon is expressed equally well in ara delta C and ara C cya crp backgrounds. The repressor form of ara C protein is able to repress the constitutive synthesis due to the ara Xc allele.

摘要

含有调节基因araC缺失的大肠杆菌B/r菌株是Ara-。分离出这些菌株生长缓慢的回复突变体，并命名为aralc，因为它们在控制位点aral中含有第二个突变，该突变允许araBAD操纵子进行低水平的组成型表达（恩格尔斯伯特等人，1969年）。我们对aralcΔC菌株进行诱变，并选择在矿物L-阿拉伯糖培养基中生长更快的突变体。这些新的突变称为araXc，定位非常接近原始的aralc突变，且位于araB和araC之间的控制位点区域。与aralcΔC亲本相比，aralcXcΔC菌株中araBAD操纵子的组成型表达水平更高。araXc突变是顺式作用的，并降低了araBAD操纵子对分解代谢物阻遏的敏感性。araBAD操纵子在araΔC和ara C cya crp背景中的表达同样良好。ara C蛋白的阻遏物形式能够抑制由于ara Xc等位基因导致的组成型合成。