Newman J D, Winslow J T, Murphy D L
Laboratory of Comparative Ethology, NICHD, NIH, Bethesda, MD 20892.
Brain Res. 1991 Jan 4;538(1):24-8. doi: 10.1016/0006-8993(91)90371-2.
The acute effects of monoamine oxidase inhibitors L-deprenyl (0.5-5.0 mg/kg), clorgyline (1.0-10.0 mg/kg), and milacemide (100-400 mg/kg) on the behavior of adult male squirrel monkeys were examined during brief social separations beginning 60 min after subcutaneous drug administration. All three drugs selectively reduced the rate of calling during social separation at doses which did not affect time spent in locomotion, nor the frequency of vigilance-checking. Deprenyl and milacemide, but not clorgyline, produced concurrent decreases in locomotion at the higher doses tested. At threshold doses, clorgyline, but not deprenyl or milacemide, increased call duration and decreased call peak frequency compared to vehicle control values. Plasma levels of MHPG were decreased by an optimal dose of clorgyline but not by deprenyl or milacemide, indicating that substrate specificity was maintained at the drug doses employed. We conclude that different MAO substrates mediate different aspects of vocal and nonvocal behavior in adult male squirrel monkeys.
在皮下注射药物60分钟后开始的短暂社会隔离期间，研究了单胺氧化酶抑制剂L-司来吉兰（0.5 - 5.0毫克/千克）、氯吉兰（1.0 - 10.0毫克/千克）和米拉酰胺（100 - 400毫克/千克）对成年雄性松鼠猴行为的急性影响。所有这三种药物在不影响运动时间和警惕检查频率的剂量下，选择性地降低了社会隔离期间的呼叫率。在测试的较高剂量下，司来吉兰和米拉酰胺，但不是氯吉兰，同时导致运动减少。在阈值剂量下，与载体对照值相比，氯吉兰增加了呼叫持续时间并降低了呼叫峰值频率，但司来吉兰或米拉酰胺没有。氯吉兰的最佳剂量降低了血浆中MHPG的水平，但司来吉兰或米拉酰胺没有，这表明在所使用的药物剂量下保持了底物特异性。我们得出结论，不同的单胺氧化酶底物介导成年雄性松鼠猴发声和非发声行为的不同方面。
