近红外光谱法对大鼠脑组织中C6胶质瘤散射系数降低的活体检测

In vivo detection of reduced scattering coefficient of C6 glioma in rat brain tissue by near-infrared spectroscopy.

作者信息

Dai Lijuan, Qian Zhiyu, Li Kuanzheng, Yang Tianming, Wang Huinan

机构信息

Nanjing University of Aeronautics and Astronautics, Department of Biomedical Engineering, No. 29 Yuado Street, Nanjing, Jiangsu 210016, China.

出版信息

J Biomed Opt. 2008 Jul-Aug;13(4):044003. doi: 10.1117/1.2957974.

DOI:10.1117/1.2957974

PMID:19021331

Abstract

The purpose of this study is to investigate the reduced scattering coefficient of C6 glioma by the near-infrared (NIR) technique. Light scattering properties of C6 glioma in brain tissue is measured by NIR spectroscopy within the wavelength range from 700 to 850 nm. C6 gliomas were implanted in rats' right brains. The scattering properties of the left and right target corresponding to the position of normal and tumor tissue were measured by a bifurcated needle probe on postoperative days 3, 10, and 17. The results show that there was no significant difference in reduced scattering coefficient between left and right brain tissue at postoperative day 3, but significant decreases were found between left and right brains at postoperative days 10 and 17. This study proved our initial hypothesis that the NIR technique may have a potential for clinical application in brain muglioma diagnosis.

摘要

本研究的目的是通过近红外（NIR）技术研究C6胶质瘤的约化散射系数。在700至850nm波长范围内，采用近红外光谱法测量脑组织中C6胶质瘤的光散射特性。将C6胶质瘤植入大鼠右脑。在术后第3、10和17天，用分叉针探头测量正常组织和肿瘤组织位置对应的左右目标的散射特性。结果显示，术后第3天左右脑组织的约化散射系数无显著差异，但术后第10天和17天左右脑之间有显著降低。本研究证实了我们最初的假设，即近红外技术在脑胶质瘤诊断中可能具有临床应用潜力。