Taylor Kathryn M
Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff, UK.
Biochem Soc Trans. 2008 Dec;36(Pt 6):1247-51. doi: 10.1042/BST0361247.
Zinc, essential for normal cell growth, is tightly controlled in cells by two families of zinc transporters. The aberrant expression of zinc transporters from the LIV-1 family of ZIP (Zrt/Irt-like protein) transporters is increasingly being implicated in a variety of disease states. In the present paper, I describe a mechanism for the role of ZIP7 in the progression of breast cancer, identifying it as a new target in breast cancer. Furthermore, I document a link between another zinc transporter, LIV-1, and breast cancer metastasis, identifying it as a potential new prognostic indicator of breast cancer spread.
锌对于正常细胞生长至关重要，在细胞内由两类锌转运蛋白严格调控。ZIP（Zrt/Irt样蛋白）转运蛋白家族中LIV-1家族的锌转运蛋白异常表达越来越多地与多种疾病状态相关。在本文中，我描述了ZIP7在乳腺癌进展中的作用机制，将其确定为乳腺癌的一个新靶点。此外，我记录了另一种锌转运蛋白LIV-1与乳腺癌转移之间的联系，将其确定为乳腺癌扩散的一个潜在新预后指标。
