Mehta Ishita S, Elcock Lauren S, Amira Manelle, Kill Ian R, Bridger Joanna M
Division of Biosciences, Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, School of Health Sciences and Social Care, Brunel University, Uxbridge, UK.
Biochem Soc Trans. 2008 Dec;36(Pt 6):1384-8. doi: 10.1042/BST0361384.
Rapid interphase chromosome territory repositioning appears to function through the action of nuclear myosin and actin, in a nuclear motor complex. We have found that chromosome repositioning when cells leave the cell cycle is not apparent in cells that have mutant lamin A or that are lacking emerin. We discuss the possibility that there is a functional intranuclear complex comprising four proteins: nuclear actin, lamin A, emerin and nuclear myosin. If any of the components are lacking or aberrant, then the nuclear motor complex involved in moving chromosomes or genes will be dysfunctional, leading to an inability to move chromosomes in response to signalling events.
快速的间期染色体区域重定位似乎是通过核肌球蛋白和肌动蛋白在一个核运动复合体中的作用来发挥功能的。我们发现，在具有突变型核纤层蛋白A或缺乏emerin的细胞中，细胞离开细胞周期时的染色体重定位并不明显。我们讨论了存在一种由四种蛋白质组成的功能性核内复合体的可能性：核肌动蛋白、核纤层蛋白A、emerin和核肌球蛋白。如果任何一个组分缺失或异常，那么参与移动染色体或基因的核运动复合体将功能失调，导致无法响应信号事件而移动染色体。
