Shimokata K, Saka H, Murate T, Hasegawa Y, Hasegawa T
First Department of Medicine, Nagoya University School of Medicine, Japan.
Chest. 1991 May;99(5):1103-7. doi: 10.1378/chest.99.5.1103.
Tuberculous pleurisy is a good model for resolution of local cellular immunity. It would be expected that tuberculous pleural fluid contains a variety of immunologically important cytokines because of the accumulation of immunocompetent cells in the pleural cavity. We studied interleukin 1 (IL-1), interleukin 2 (IL-2), and interferon gamma (IFN-gamma) levels in pleural fluid of 20 patients with tuberculous pleurisy and compared them with those in pleural fluid of 20 patients with malignant pleurisy. We also evaluated adenosine deaminase (ADA) levels in both effusions. Tuberculous pleural fluid had higher levels of IL-1, IL-2, IFN-gamma, and ADA than malignant pleural fluid. Although the difference of IL-1 level between tuberculous and malignant pleural fluid was modest, that of IL-2, IFN-gamma, and ADA was dominant. These findings suggest that activated T lymphocytes in tuberculous pleural fluid concern the production of lymphokines at the morbid site and they effectively exert local cellular immunity through the action of such lymphokines.
结核性胸膜炎是局部细胞免疫消退的一个良好模型。由于胸膜腔内免疫活性细胞的积聚，预计结核性胸腔积液含有多种具有免疫重要性的细胞因子。我们研究了20例结核性胸膜炎患者胸腔积液中的白细胞介素1（IL-1）、白细胞介素2（IL-2）和干扰素γ（IFN-γ）水平，并将其与20例恶性胸膜炎患者胸腔积液中的水平进行比较。我们还评估了两种积液中的腺苷脱氨酶（ADA）水平。结核性胸腔积液中的IL-1、IL-2、IFN-γ和ADA水平高于恶性胸腔积液。虽然结核性和恶性胸腔积液中IL-1水平的差异不大，但IL-2、IFN-γ和ADA的差异显著。这些发现表明，结核性胸腔积液中活化的T淋巴细胞与病变部位淋巴因子的产生有关，并且它们通过此类淋巴因子的作用有效地发挥局部细胞免疫。
