Akarsu Saadet, Kurt A Nese Citak, Dogan Yasar, Yilmaz Erdal, Godekmerdan Ahmet, Aygun A Denizmen
Department of Pediatrics, Medical faculty, Firat university, Elazig, Turkey.
Mediators Inflamm. 2005 Feb 24;2005(1):2-8. doi: 10.1155/MI.2005.2.
The aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-8 in pleural fluids were statistically significantly higher in the transudate group compared with those of the exudate group. The levels of IL-1 beta, IL-6, and IL-8 were also found to be statistically significantly higher in the empyema group compared with both the parapneumonic and the tuberculous pleural effusion groups. The levels of IL-2 and IL-6 were detected to be statistically significantly higher in the tuberculous pleural effusion group in comparison with those of the parapneumonic effusion group. The results showed that pleural fluids IL-1beta, IL-2, IL-6, and IL-8 could be used in pleural fluids exudate and transudate distinction.
目的是研究胸腔积液中白细胞介素（IL）-1β、IL-2、IL-6和IL-8水平的变化在儿童胸腔积液鉴别诊断中是否具有显著性。检测了全部36例患者胸腔积液中的IL-1β、IL-2、IL-6和IL-8水平。与渗出液组相比，漏出液组胸腔积液中IL-1β、IL-2、IL-6和IL-8水平在统计学上显著更高。与肺炎旁胸腔积液组和结核性胸腔积液组相比，脓胸组胸腔积液中IL-1β、IL-6和IL-8水平在统计学上也显著更高。与肺炎旁胸腔积液组相比，结核性胸腔积液组中IL-2和IL-6水平在统计学上显著更高。结果表明，胸腔积液中的IL-1β、IL-2、IL-6和IL-8可用于区分胸腔积液的渗出液和漏出液。
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