Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.
Acta Ophthalmol. 2010 Feb;88(1):60-4. doi: 10.1111/j.1755-3768.2008.01401.x. Epub 2009 Nov 18.
To investigate the relationship between filtering bleb function and Stratus optical coherence tomography (OCT) images.
We studied 72 eyes of 65 consecutive patients who had a fornix-based conjunctival flap in primary trabeculectomy with mitomycin C (MMC). Filtering blebs with various types of glaucoma were examined using Stratus OCT. Success rates were defined as intraocular pressure (IOP) < or = 15 mmHg and IOP reduction > or = 25% without medication or additional surgery. Success rates among classified groups were compared using Kaplan-Meier survival curves and the log-rank test.
Blebs were classified into three different categories on the basis of the following Stratus OCT patterns: cystoid type (multiple cysts inside the bleb; 17 eyes), diffuse type (low to high reflective areas that were mixed inside the bleb; 31 eyes) and layer type (medium to high reflective layer inside the bleb; 24 eyes). Success rates in the cystoid-, diffuse- and layer-type blebs were 94%, 97% and 75% (P = 0.02), respectively.
In trabeculectomy with MMC and a fornix-based conjunctival flap, there is a significant association between the success rates and the postoperative Stratus OCT findings of filtering blebs.
研究滤过泡功能与 Stratus 光学相干断层扫描（OCT）图像之间的关系。
我们研究了 65 例连续患者的 72 只眼，这些患者均行以穹隆为基底的结膜瓣的原发性小梁切除术联合丝裂霉素 C（MMC）。应用 Stratus OCT 检查各种类型青光眼的滤过泡。将成功定义为眼压（IOP）≤15mmHg 且无需药物或进一步手术即可降低 IOP≥25%。使用 Kaplan-Meier 生存曲线和对数秩检验比较分类组之间的成功率。
根据以下 Stratus OCT 模式将滤过泡分为三种不同类型：囊泡型（滤过泡内有多个囊肿；17 只眼）、弥漫型（滤过泡内混合有低至高反射区；31 只眼）和层状型（滤过泡内有中至高反射层；24 只眼）。囊泡型、弥漫型和层状型滤过泡的成功率分别为 94%、97%和 75%（P=0.02）。
在 MMC 联合以穹隆为基底的结膜瓣的小梁切除术中，滤过泡的术后 Stratus OCT 表现与成功率之间存在显著关联。
