Department of Geriatric Medicine, University Medical Center, Utrecht, The Netherlands.
Neurobiol Aging. 2010 Oct;31(10):1758-65. doi: 10.1016/j.neurobiolaging.2008.10.001. Epub 2008 Dec 3.
It has been suggested that low levels of estradiol and testosterone increase dementia risk. However, results of the existing observational studies examining associations of endogenous sex hormones with cognition and dementia are conflicting. A possible explanation for these inconsistent findings could be the involvement of sex hormone-binding globulin (SHBG) in regulating sex hormone levels. In the present study, we examined whether SHBG levels were associated with development of AD and overall dementia in a cohort of elderly men and women free of dementia at baseline. We observed that in both men and women higher levels of SHBG were associated with an increased risk for AD and overall dementia. These results were independent of vascular risk factors and bioactive hormone levels. Whether SHBG is causally related to dementia or whether it is a surrogate marker for rate of biological aging and increased risk or for preclinical stage of dementia has to be elucidated.
有人认为，雌二醇和睾酮水平低会增加痴呆症的风险。然而，现有的观察性研究检查内源性性激素与认知和痴呆症之间的关联的结果存在冲突。这些不一致发现的一个可能解释可能是性激素结合球蛋白 (SHBG) 参与调节性激素水平。在本研究中，我们在一组基线时无痴呆的老年男女队列中检查了 SHBG 水平是否与 AD 的发展和总体痴呆有关。我们观察到，在男性和女性中，较高的 SHBG 水平与 AD 和总体痴呆的风险增加有关。这些结果独立于血管危险因素和生物活性激素水平。SHBG 是否与痴呆症有关，或者它是否是生物学衰老速度和风险增加或痴呆症临床前阶段的替代标志物，还有待阐明。
