de la Fontaine L, Schwarz M J, Eser D, Müller N, Rupprecht R, Zwanzger P
Department of Psychiatry, Ludwig-Maximilian-University, Nussbaumstr. 7, 80336 Munich, Germany.
J Neural Transm (Vienna). 2009 Jun;116(6):699-702. doi: 10.1007/s00702-008-0140-6. Epub 2008 Nov 21.
Since little is known concerning regulation of immunological parameters in rapid changing psychiatric states like panic attacks, we measured cytokines at different time points in healthy subjects, which underwent experimental panic induction using the CCK-4 paradigm. Apart from a challenge related IL-6 increase, we could not observe any changes of neuroimmunological markers in relation to acute anxiety with regard to time and group. Herein we conducted for the first time a new approach to immunological research in panic disorder, suggesting immune changes are more related to long term disease stress.
由于对于像惊恐发作这样快速变化的精神状态下免疫参数的调节知之甚少，我们在健康受试者的不同时间点测量了细胞因子，这些受试者使用CCK-4范式接受了实验性惊恐诱发。除了与刺激相关的白细胞介素-6增加外，我们在时间和组间方面均未观察到与急性焦虑相关的任何神经免疫标志物变化。在此，我们首次对惊恐障碍的免疫学研究采用了一种新方法，表明免疫变化与长期疾病应激的关系更为密切。
