光亮大苞姜中一种新型乙酰胆碱酯酶抑制剂——大苞姜苷的全核磁共振波谱归属及绝对构型
Complete NMR assignment and absolute configuration of feronielloside, a new acetylcholinesterase inhibitor from Feroniella lucida.
作者信息
Phoopichayanun Chalouyluk, Phuwapraisirisan Preecha, Tip-Pyang Santi, Jongaramruong Jongkolnee
机构信息
Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand.
出版信息
Nat Prod Res. 2008;22(15):1297-303. doi: 10.1080/14786410801980626.
Feronielloside (1), a new furanocoumarin glycoside, was isolated from roots of Feroniella lucida. The structure of 1 was elucidated by combined spectroscopic and chemical analysis. The absolute configuration of the chiral center in geranyl-derived side chain was confirmed by modified Mosher's method. Feronielloside inhibited acetylcholinesterase with IC(50) value of 24.7 mM.
费罗尼苷（1）是一种新的呋喃香豆素糖苷，从亮叶费罗尼木的根中分离得到。通过光谱和化学分析相结合的方法阐明了1的结构。香叶基衍生侧链上手性中心的绝对构型通过改进的莫舍尔方法得以确定。费罗尼苷对乙酰胆碱酯酶有抑制作用，IC（50）值为24.7 mM。
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